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- W2000246144 abstract "Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone (R‐CHOP) is one of the most frequently applied initial treatments for indolent B‐cell non‐Hodgkin lymphoma (B‐NHL); however, information on its long‐term outcome is limited. Untreated patients in the concurrent arm (Arm C) received six R (375 mg/m 2 ) treatments, 2 days prior to each cycle of CHOP, and patients in the sequential arm (Arm S) received 6 weekly R (375 mg/m 2 ) treatments following six cycles of CHOP. Sixty‐nine patients were randomized but two patients were withdrawn before receiving the protocol treatment. Sixty‐five patients (94%) had follicular lymphoma, and 37 (55%) were at low risk, 23 (34%) at intermediate risk and seven (10%) at high risk according to the Follicular Lymphoma International Prognostic Index. We previously reported that the overall response rate (ORR) in Arm C and in Arm S was 94% and 97%, respectively. The median progression‐free survival (PFS)/7‐year PFS rate in Arm C, Arm S and all 67 assessable patients was 2.4 years/23% (95% confidence interval [CI], 9–40%), 3.8 years/41% (95% CI, 23–57%) and 2.8 years/32% (95% CI, 20–45%), respectively. There was no significant difference between the two arms ( P = 0.107). The overall survival (OS) of the 67 patients was 95% at 7 years. In conclusion, R‐CHOP is a highly effective initial treatment for untreated indolent B‐NHL in terms of ORR and OS; however, its long‐term PFS is not good enough either in concurrent or sequential combination, warranting further investigations on post‐remission therapy. ( Cancer Sci 2010; 101: 2579–2585)" @default.
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- W2000246144 date "2010-11-16" @default.
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- W2000246144 title "Randomized phase II study of concurrent and sequential combinations of rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy in untreated indolent B-cell non-Hodgkin lymphoma: 7-year follow-up results" @default.
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- W2000246144 doi "https://doi.org/10.1111/j.1349-7006.2010.01703.x" @default.
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