Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000246196> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2000246196 endingPage "470" @default.
- W2000246196 startingPage "462" @default.
- W2000246196 abstract "Forty-seven peroral biopsy specimens of duodenojejunal mucosa showing convolutions were obtained from patients with a variety of clinical disorders. These mucosal samples were divided into three groups according to the extent of the convolutions and the severity of the accompanying histopathological changes; the cytokinetic status of the crypts in the three groups was then analysed and compared. Those in which the mucosae were predominantly or totally convoluted (group 3) showed the most notable cytokinetic changes: crypts were hyperplastic and crypt cell production rate was markedly increased compared with the other two groups and with morphologically normal control mucosae. In the case of one patient with mucosal changes of group 3 severity, additional studies were carried out using vincristine to produce metaphase arrest. The cell cycle time of 27 hours was greatly shortened compared with a control value of 45 hours.We find that the presence of convolutions in small-intestinal mucosal biopsy specimens is accompanied by an increase in the rate of cell production from the crypts, which is presumably related directly or indirectly to the rate of loss of mature enterocytes from the surface of the mucosa. Furthermore, an increase in the proportion of convolutions may reflect an increase in the rates of cell production and cell loss. In the group 3 convoluted mucosae the cytokinetic profile of the crypts resembled that of some of the flat avillous coeliac mucosae previously studied although the rates of cell production did not reach the levels attained by the most productive of the flat coeliac mucosae." @default.
- W2000246196 created "2016-06-24" @default.
- W2000246196 creator A5016027484 @default.
- W2000246196 creator A5085100825 @default.
- W2000246196 creator A5085873455 @default.
- W2000246196 creator A5086739699 @default.
- W2000246196 date "1979-05-01" @default.
- W2000246196 modified "2023-09-24" @default.
- W2000246196 title "Cytokinetic studies of crypts in convoluted human small-intestinal mucosa" @default.
- W2000246196 cites W1970466323 @default.
- W2000246196 cites W2002746277 @default.
- W2000246196 cites W2004991933 @default.
- W2000246196 cites W2008642306 @default.
- W2000246196 cites W2016670234 @default.
- W2000246196 cites W2042120801 @default.
- W2000246196 cites W2053668172 @default.
- W2000246196 cites W2060317801 @default.
- W2000246196 cites W2066927539 @default.
- W2000246196 cites W2070915153 @default.
- W2000246196 cites W2075486633 @default.
- W2000246196 cites W2088544518 @default.
- W2000246196 cites W2099172430 @default.
- W2000246196 cites W2108608177 @default.
- W2000246196 cites W2121874489 @default.
- W2000246196 cites W2146604216 @default.
- W2000246196 cites W2398441322 @default.
- W2000246196 cites W2419316189 @default.
- W2000246196 cites W2885982543 @default.
- W2000246196 cites W30991158 @default.
- W2000246196 cites W4297851963 @default.
- W2000246196 doi "https://doi.org/10.1136/jcp.32.5.462" @default.
- W2000246196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1145708" @default.
- W2000246196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/469003" @default.
- W2000246196 hasPublicationYear "1979" @default.
- W2000246196 type Work @default.
- W2000246196 sameAs 2000246196 @default.
- W2000246196 citedByCount "12" @default.
- W2000246196 countsByYear W20002461962012 @default.
- W2000246196 countsByYear W20002461962018 @default.
- W2000246196 crossrefType "journal-article" @default.
- W2000246196 hasAuthorship W2000246196A5016027484 @default.
- W2000246196 hasAuthorship W2000246196A5085100825 @default.
- W2000246196 hasAuthorship W2000246196A5085873455 @default.
- W2000246196 hasAuthorship W2000246196A5086739699 @default.
- W2000246196 hasBestOaLocation W20002461961 @default.
- W2000246196 hasConcept C104317684 @default.
- W2000246196 hasConcept C126322002 @default.
- W2000246196 hasConcept C134018914 @default.
- W2000246196 hasConcept C142724271 @default.
- W2000246196 hasConcept C1491633281 @default.
- W2000246196 hasConcept C2775934546 @default.
- W2000246196 hasConcept C3019368612 @default.
- W2000246196 hasConcept C30481170 @default.
- W2000246196 hasConcept C55493867 @default.
- W2000246196 hasConcept C66090201 @default.
- W2000246196 hasConcept C70278784 @default.
- W2000246196 hasConcept C71924100 @default.
- W2000246196 hasConcept C86803240 @default.
- W2000246196 hasConceptScore W2000246196C104317684 @default.
- W2000246196 hasConceptScore W2000246196C126322002 @default.
- W2000246196 hasConceptScore W2000246196C134018914 @default.
- W2000246196 hasConceptScore W2000246196C142724271 @default.
- W2000246196 hasConceptScore W2000246196C1491633281 @default.
- W2000246196 hasConceptScore W2000246196C2775934546 @default.
- W2000246196 hasConceptScore W2000246196C3019368612 @default.
- W2000246196 hasConceptScore W2000246196C30481170 @default.
- W2000246196 hasConceptScore W2000246196C55493867 @default.
- W2000246196 hasConceptScore W2000246196C66090201 @default.
- W2000246196 hasConceptScore W2000246196C70278784 @default.
- W2000246196 hasConceptScore W2000246196C71924100 @default.
- W2000246196 hasConceptScore W2000246196C86803240 @default.
- W2000246196 hasIssue "5" @default.
- W2000246196 hasLocation W20002461961 @default.
- W2000246196 hasLocation W20002461962 @default.
- W2000246196 hasLocation W20002461963 @default.
- W2000246196 hasLocation W20002461964 @default.
- W2000246196 hasOpenAccess W2000246196 @default.
- W2000246196 hasPrimaryLocation W20002461961 @default.
- W2000246196 hasRelatedWork W1001040782 @default.
- W2000246196 hasRelatedWork W1964154064 @default.
- W2000246196 hasRelatedWork W2003788673 @default.
- W2000246196 hasRelatedWork W2021491166 @default.
- W2000246196 hasRelatedWork W2028081247 @default.
- W2000246196 hasRelatedWork W2040509494 @default.
- W2000246196 hasRelatedWork W2107589992 @default.
- W2000246196 hasRelatedWork W2537202170 @default.
- W2000246196 hasRelatedWork W2913015173 @default.
- W2000246196 hasRelatedWork W3029845688 @default.
- W2000246196 hasVolume "32" @default.
- W2000246196 isParatext "false" @default.
- W2000246196 isRetracted "false" @default.
- W2000246196 magId "2000246196" @default.
- W2000246196 workType "article" @default.