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- W2000247111 abstract "Mucociliary transport in the rat trachea was monitored through a surgical window for approximately one hour. Rates were grouped according to 5-min intervals which were examined with analyses of variance. Rates were consistent within each rat, although inter-animal variability was pronounced. Unstimulated transport involved minimal amounts of mucus and averaged 4.5 ± 1.4 mm/min. Pilocarpine, presumably a secretagogue, caused a sustained (55 ± 10 min) increase to 5.7 ± 1.6 mm/min. Isoproterenol, presumably a cilioexcitatory agent, caused a brief (14 ± 6 min) peak in transport at 6.4 ± 2.1 mm/min. There were slow and fast animals which remained relatively slow or fast during and after treatment, indicating that each rat had an individual base-line determined by factors other than those susceptible to stimulation. Transport ceased almost at once throughout the airways, as mucus became scanty although ciliary activity was wide-spread. It was concluded that both types of response revealed different mechanisms for the physiological modulation of mucociliary transport." @default.
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- W2000247111 date "1993-05-01" @default.
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- W2000247111 title "Cholinergic and adrenergic stimulation of mucociliary trasport in the rat trachea" @default.
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- W2000247111 doi "https://doi.org/10.1016/0034-5687(93)90039-d" @default.
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