FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000247665> ?p ?o ?g. }

• W2000247665 endingPage "597" @default.
• W2000247665 startingPage "581" @default.
• W2000247665 abstract "Toxoplasma gondii is an intracellular parasitic protozoan that infects approximately a billion people worldwide. Infection with T. gondii represents a major health problem for immunocompromised individuals, such as AIDS patients, organ transplant recipients, and the unborn children of infected mothers. Currently available drugs usually do not eradicate infection and as many as 50% of the patients do not respond to this therapy. Furthermore, they are ineffective against T. gondii tissue cysts. In addition, prolonged exposure to these drugs induces serious host toxicity forcing the discontinuation of the therapy. Finally, there is no effective vaccine currently available for the treatment of toxoplasmosis. Therefore, it is necessary to develop new and effective drugs for the treatment and management of toxoplasmosis. The rational design of a drug depends on the exploitation of fundamental biochemical or physiological differences between pathogens and their host. Some of the most striking differences between T. gondii and their mammalian host are found in purine metabolism. T. gondii, like most parasites studied, lack the ability to synthesize purines do novo and depend on the salvage of purines from their host to satisfy their requirements of purines. In this respect, the salvage of adenosine is the major source of purines in T. gondii. Therefore, interference with adenosine uptake and metabolism in T. gondii can be selectively detrimental to the parasite. The host cells, on the other hand, can still obtain their purine requirements by their de novo pathways. This review will focus on the broad aspects of the adenosine transport and the enzyme adenosine kinase (EC 2.7.1.20) which are the two primary routes for adenosine utilization in T. gondii, in an attempt to illustrate their potentials as targets for chemotherapy against this parasite. Keywords: Toxoplasma gondii, purines, adenosine, transport, adenosine kinase, subversive substrates, chemotherapy" @default.
• W2000247665 created "2016-06-24" @default.
• W2000247665 creator A5077433262 @default.
• W2000247665 date "2007-02-01" @default.
• W2000247665 modified "2023-09-26" @default.
• W2000247665 title "Adenosine Metabolism in Toxoplasma gondii: Potential Targets for Chemotherapy" @default.
• W2000247665 cites W1564988623 @default.
• W2000247665 cites W1604694310 @default.
• W2000247665 cites W1909710140 @default.
• W2000247665 cites W1968972077 @default.
• W2000247665 cites W1972946444 @default.
• W2000247665 cites W1973045078 @default.
• W2000247665 cites W1977150380 @default.
• W2000247665 cites W1979453000 @default.
• W2000247665 cites W1985894949 @default.
• W2000247665 cites W1988971616 @default.
• W2000247665 cites W1992665460 @default.
• W2000247665 cites W1992771067 @default.
• W2000247665 cites W1997982046 @default.
• W2000247665 cites W1998207274 @default.
• W2000247665 cites W2000480344 @default.
• W2000247665 cites W2000497556 @default.
• W2000247665 cites W2000702815 @default.
• W2000247665 cites W2016129312 @default.
• W2000247665 cites W2020772247 @default.
• W2000247665 cites W2025572792 @default.
• W2000247665 cites W2027320131 @default.
• W2000247665 cites W2028569318 @default.
• W2000247665 cites W2029365127 @default.
• W2000247665 cites W2036330755 @default.
• W2000247665 cites W2037333058 @default.
• W2000247665 cites W2042674392 @default.
• W2000247665 cites W2051940183 @default.
• W2000247665 cites W2056462006 @default.
• W2000247665 cites W2073695321 @default.
• W2000247665 cites W2075411218 @default.
• W2000247665 cites W2088164381 @default.
• W2000247665 cites W2118426544 @default.
• W2000247665 cites W2141773320 @default.
• W2000247665 cites W2315501000 @default.
• W2000247665 cites W2577020825 @default.
• W2000247665 cites W35131301 @default.
• W2000247665 doi "https://doi.org/10.2174/138161207780162836" @default.
• W2000247665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17346176" @default.
• W2000247665 hasPublicationYear "2007" @default.
• W2000247665 type Work @default.
• W2000247665 sameAs 2000247665 @default.
• W2000247665 citedByCount "23" @default.
• W2000247665 countsByYear W20002476652012 @default.
• W2000247665 countsByYear W20002476652015 @default.
• W2000247665 countsByYear W20002476652017 @default.
• W2000247665 countsByYear W20002476652018 @default.
• W2000247665 countsByYear W20002476652020 @default.
• W2000247665 countsByYear W20002476652021 @default.
• W2000247665 countsByYear W20002476652022 @default.
• W2000247665 crossrefType "journal-article" @default.
• W2000247665 hasAuthorship W2000247665A5077433262 @default.
• W2000247665 hasConcept C159654299 @default.
• W2000247665 hasConcept C169586020 @default.
• W2000247665 hasConcept C181199279 @default.
• W2000247665 hasConcept C203014093 @default.
• W2000247665 hasConcept C2776476023 @default.
• W2000247665 hasConcept C2776991684 @default.
• W2000247665 hasConcept C2778062946 @default.
• W2000247665 hasConcept C2778128430 @default.
• W2000247665 hasConcept C2780876210 @default.
• W2000247665 hasConcept C34628245 @default.
• W2000247665 hasConcept C55493867 @default.
• W2000247665 hasConcept C86803240 @default.
• W2000247665 hasConcept C98274493 @default.
• W2000247665 hasConceptScore W2000247665C159654299 @default.
• W2000247665 hasConceptScore W2000247665C169586020 @default.
• W2000247665 hasConceptScore W2000247665C181199279 @default.
• W2000247665 hasConceptScore W2000247665C203014093 @default.
• W2000247665 hasConceptScore W2000247665C2776476023 @default.
• W2000247665 hasConceptScore W2000247665C2776991684 @default.
• W2000247665 hasConceptScore W2000247665C2778062946 @default.
• W2000247665 hasConceptScore W2000247665C2778128430 @default.
• W2000247665 hasConceptScore W2000247665C2780876210 @default.
• W2000247665 hasConceptScore W2000247665C34628245 @default.
• W2000247665 hasConceptScore W2000247665C55493867 @default.
• W2000247665 hasConceptScore W2000247665C86803240 @default.
• W2000247665 hasConceptScore W2000247665C98274493 @default.
• W2000247665 hasIssue "6" @default.
• W2000247665 hasLocation W20002476651 @default.
• W2000247665 hasLocation W20002476652 @default.
• W2000247665 hasOpenAccess W2000247665 @default.
• W2000247665 hasPrimaryLocation W20002476651 @default.
• W2000247665 hasRelatedWork W1963540850 @default.
• W2000247665 hasRelatedWork W1979325550 @default.
• W2000247665 hasRelatedWork W2016129312 @default.
• W2000247665 hasRelatedWork W2042674392 @default.
• W2000247665 hasRelatedWork W2052699360 @default.
• W2000247665 hasRelatedWork W2070025735 @default.
• W2000247665 hasRelatedWork W2097792399 @default.
• W2000247665 hasRelatedWork W2280573525 @default.
• W2000247665 hasRelatedWork W2403534900 @default.
• W2000247665 hasRelatedWork W4241482586 @default.

• next