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- W2000247726 abstract "Background Deep vein thrombosis (DVT) occurs with high prevalence in association with the Factor V Leiden (R506Q) mutation, whereas most evidence suggests no correlation with clinical arterial thrombosis. Objective This study compared arterial to venous thrombosis in the mutationally analogous Factor V Leiden mouse. Methods Three separate vascular thrombosis models were evaluated in Fv+/+ (wild-type), FvQ/+ (heterozygous) and FvQ/Q (homozygous) Factor V Leiden mice. Results In a FeCl3-induced arterial thrombosis model, no statistical differences among the three genotypes were found in the time to thrombotic occlusion. In contrast, FvQ/+ and FvQ/Q mice demonstrated larger femoral vein thrombi at 30 and 60 min compared to wild-types, with FvQ/Q mice having statistically larger thrombi than both wild-type and FvQ/+ mice at 10 and 60 min and 24 h (p<0.05). In a model of thrombotic occlusion following arterial and venous anastomotic repair, both FvQ/+ and FvQ/Q mice had higher rates of venous thrombosis than wild-types, but only FvQ/Q homozygotes showed a statistically greater arterial occlusion rate than wild-types. Conclusion The Factor V Leiden mouse demonstrated a greater propensity for venous vs. arterial thrombosis, paralleling clinical epidemiologic findings and supporting its use for research on deep vein thrombosis." @default.
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- W2000247726 date "2007-01-01" @default.
- W2000247726 modified "2023-10-18" @default.
- W2000247726 title "Increased venous versus arterial thrombosis in the Factor V Leiden mouse" @default.
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- W2000247726 doi "https://doi.org/10.1016/j.thromres.2006.02.014" @default.
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