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- W2000248601 abstract "Fusarium equiseti NRRL 5537 grown on an autoclaved white corn grit medium for 3 to 4 weeks at room temperature produced a substance in excess of 5 g/kg of substrate that inhibited some gram-positive bacteria including mycobacteria. Most Bacillus subtilis, Mycobacterium phlei , and Staphylococcus aureus strains were inhibited when 1 μg of the antibiotic per ml was incorporated into the culture medium. Except for Neisseria perflava , gram-negative bacteria, yeasts, and molds were not inhibited by 128 μg/ml. The antibiotic was recovered as a white powder, had a melting point of 65 to 66 C, and had an intraperitoneal mean lethal dose in white mice of 63 mg/kg of body weight. In thin-layer chromatographic analysis the compound appeared as a single spot in two different solvent systems. Mass spectrometry determined that the molecular weight of the antibiotic was 373 with a molecular formula of C 22 H 31 NO 4 . Chemical microanalysis was in accord with the formula." @default.
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- W2000248601 date "1974-06-01" @default.
- W2000248601 modified "2023-10-01" @default.
- W2000248601 title "Antibiotic Produced by <i>Fusarium equiseti</i> NRRL 5537" @default.
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- W2000248601 doi "https://doi.org/10.1128/aac.5.6.634" @default.
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