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• W2000249610 abstract "Purpose Staphylococcus aureus and Pseudomonas aeruginosa are frequently isolated from biofilm-associated orthopedic implant infections. This study assessed the activity of N-acetyl-L-cysteine at inhibitory and subinhibitory concentrations against biofilm formed by S. aureus and P. aeruginosa on prosthetic materials. Methods S. aureus and P. aeruginosa biofilm on smooth polyethylene and sand-blasted titanium discs was determined by means of a spectrophotometric assay before and at 3, 6, and 18 hours after addition of N-acetyl-L-cysteine. Results N-acetyl-L-cysteine was able to disaggregate biofilm produced by S. aureus and P. aeruginosa on polyethylene and titanium discs after 3 h of incubation. A different rate in eradication of biofilm produced by P. aeruginosa was seen between polyethylene and titanium (50% vs. 20% respectively vs. biofilm formed before treatment). Results were confirmed by confocal laser scanning microscopy. Conclusions The results suggest a possible role of N-acetyl-L-cysteine in the treatment of orthopedic prosthetic infections." @default.
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• W2000249610 date "2013-01-01" @default.
• W2000249610 modified "2023-10-16" @default.
• W2000249610 title "Activity of N-acetyl-L-cysteine against Biofilm of <i>Staphylococcus Aureus</i> and <i>Pseudomonas Aeruginosa</i> on Orthopedic Prosthetic Materials" @default.
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• W2000249610 doi "https://doi.org/10.5301/ijao.5000135" @default.
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