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- W2000250287 abstract "Sepsis is a severe inflammatory immune response of the host against an infectious agent or its product i.e. lipopolysaccharide (LPS). Therefore, targeting the immune system during sepsis may lower the morbidity and mortality associated with sepsis. The present study shows the protective immunomodulatory action of 2-chloroadenosine (2-CADO) in K. pneumoniae B5055 induced sepsis in male BALB/c mice. Sepsis was induced by implanting the fibrin-thrombin clot containing known amount (10(2)cfu) of Klebsiella pneumoniae B5055 into the peritoneal cavity of mice. 100% mortality with in the 5 post infection days (PIDs) was observed in control group animals. Intravenous 2-CADO (10 microg/kg/day) treatment increased in survival of animals by 70% without significantly (p>0.05) decreasing the blood bacterial load. But a significant (p<0.05) decrease in the level of inflammatory markers (TNF-alpha, il-1alpha, MDA, NO) responsible for sepsis was observed. However, serum il-10 levels were found to be significantly (p<0.05) increased with 2-CADO treatment." @default.
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- W2000250287 date "2009-12-01" @default.
- W2000250287 modified "2023-09-27" @default.
- W2000250287 title "Intravenous 2-Chloroadenosine Protects BALB/C Mice fromKlebsiella pneumoniaeB5055-Induced Sepsis by Modulating the Pro-Inflammatory Immune Response" @default.
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- W2000250287 doi "https://doi.org/10.1179/joc.2009.21.6.639" @default.
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