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- W2000250685 abstract "The differential tissue expression of thyroid hormone receptor (TR) isoforms implies that they fulfil different roles in mediating triiodothyronine (T3) regulation. We have examined the differential roles of TR isoforms in mediating T3-dependent repression of the human thyrotropin (TSH)-α subunit gene promoter in vitro, and have assessed TR binding characteristics using gel mobility shift assays. Expression of transfected TR in JEG-3 cells revealed that TRα1 and TRβ1 differentially inhibited TSHα subunit expression in the presence of T.3, with TRβ1 twice as potent as TRα1. TRα2 antagonized T3-dependent repression when coexpressed with TRα1 and TRβ1. Gel mobility shift assays, performed in the presence and absence of JEG-3 nuclear extract, demonstrated that TRβ1 bound with higher affinity to the wild-type TSHα negative thyroid hormone response element (nTRE) than TRα1. In vivo, the differential DNA binding of TR variants to nTREs may determine the ability of receptors to mediate T3-dependent repression." @default.
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- W2000250685 date "1998-07-01" @default.
- W2000250685 modified "2023-10-14" @default.
- W2000250685 title "Differential Regulation of the Human Thyrotropin α-Subunit Promoter by Thyroid Hormone Receptors α1 and β1" @default.
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- W2000250685 doi "https://doi.org/10.1089/thy.1998.8.601" @default.
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