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- W2000251131 abstract "Using an optimized HIV co-culture protocol it was possible to isolate infectious HIV-2 variants from 6 HIV-2-infected individuals who had undetectable plasma viremia and maintained high CD4+ T-cell numbers for prolonged periods. This shows for the first time that HIV-2-infected individuals with no demonstrable in vivo virus production carry replication-competent virus in peripheral blood mononuclear cells (PBMCs). The frequency of PBMCs with infectious virus was low, ranging from 0.01–0.9 infectious units per million (IUPM) CD4+ T cells with a median value of 0.2 IUPM. In comparison, viremic HIV-2-infected individuals had a 2-log higher median infectious load (36 IUPM, range 1–673; P = 0.003). HIV-2 infectious load correlated with CD4 counts (rs = −0.88, P < 0.0001). The low infectious load in aviremic HIV-2-infected persons is reminiscent of what has been observed for HIV-1 infection controlled by highly active antiretroviral therapy." @default.
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- W2000251131 date "2004-07-01" @default.
- W2000251131 modified "2023-09-26" @default.
- W2000251131 title "HIV-2-Infected Individuals With Undetectable Plasma Viremia Carry Replication-Competent Virus in Peripheral Blood Lymphocytes" @default.
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- W2000251131 doi "https://doi.org/10.1097/00126334-200407010-00003" @default.
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