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- W2000251389 endingPage "22" @default.
- W2000251389 startingPage "3" @default.
- W2000251389 abstract "Postmitotic neurons are subject to a vast array of environmental influences that require the nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic states associated with synaptic function, circuit formation, and behavioral memory. Over the last decade, much attention has been paid to the roles of transcription and chromatin regulation in guiding fundamental aspects of neuronal function. A great deal of this work has centered on neurodevelopmental and adulthood plasticity, with increased focus in the areas of neuropharmacology and molecular psychiatry. Here, we attempt to provide a broad overview of chromatin regulation, as it relates to central nervous system (CNS) function, with specific emphasis on the modes of histone posttranslational modifications, chromatin remodeling, and histone variant exchange. Understanding the functions of chromatin in the context of the CNS will aid in the future development of pharmacological therapeutics aimed at alleviating devastating neurological disorders." @default.
- W2000251389 created "2016-06-24" @default.
- W2000251389 creator A5002580760 @default.
- W2000251389 creator A5052967210 @default.
- W2000251389 creator A5075699516 @default.
- W2000251389 date "2012-07-25" @default.
- W2000251389 modified "2023-10-14" @default.
- W2000251389 title "Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity" @default.
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