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- W2000252565 abstract "Gemini surfactants are potential candidates as synthetic vectors for the delivery of genes into cells to induce protein expression. With the ultimate objective of obtaining a better understanding of the mechanism of DNA transfection, two new asymmetric gemini surfactants (py-3-12 and py-6-12) have been synthesized as fluorescence probes. The physicochemical properties and morphologies of the self-assembled aggregates formed in aqueous solution have been studied using surface tension, specific conductance, dynamic light scattering (DLS), isothermal titration calorimetry (ITC), and fluorescence techniques. The interaction between pyrene-based gemini surfactants and DNA was investigated by using UV−vis and fluorescence spectroscopy. Binding constants for the DNA (salmon sperm)-gemini lipoplexes were measured. Fluorescence studies show that excimer emission occurs upon complexation with DNA." @default.
- W2000252565 created "2016-06-24" @default.
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- W2000252565 date "2007-07-18" @default.
- W2000252565 modified "2023-10-08" @default.
- W2000252565 title "Synthesis, Characterization, and Use of Asymmetric Pyrenyl-Gemini Surfactants as Emissive Components in DNA−Lipoplex Systems" @default.
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- W2000252565 doi "https://doi.org/10.1021/la0635911" @default.
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