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• W2000253046 abstract "Recently, it has been shown that the prenatal vitamin D3 depletion is associated with altered brain development. Given the antiproliferative and pro-apoptotic properties of vitamin D3 in various cell types, we examined the effects of maternal vitamin D3 deprivation on cell proliferation and apoptosis within the rat cortex at several developmental stages. Our results confirm that vitamin D3 regulates these processes in the developing brain at both cellular and molecular levels. Compared to control animals, the embryos and pups from vitamin D3 depleted mothers had significantly less apoptotic cells, this finding being most pronounced at birth. Additionally, there were significantly more mitotic cells but this was not associated with any particular developmental period. Targeted gene arrays specific for apoptosis and cell cycle genes confirmed a pattern of transcription deregulation in the deplete group consistent with the known properties of vitamin D3. While most current vitamin D3 research is focussed on the pro-apoptotic and prodifferentiating properties of vitamin D3 as adjuncts for the treatment of cancers, our findings highlight the important role that this hormone plays in normal development via these same properties specifically in the brain." @default.
• W2000253046 created "2016-06-24" @default.
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• W2000253046 date "2004-10-01" @default.
• W2000253046 modified "2023-10-02" @default.
• W2000253046 title "Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development" @default.
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• W2000253046 doi "https://doi.org/10.1016/j.devbrainres.2004.07.013" @default.
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