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- W2000255604 abstract "Insulin-like growth factor-1 (IGF-1) is related to factors that are socially patterned and may play a role in social differences in the development of morbidities including disability. Our aim is to examine whether there are social differences in IGF-1 in a cohort of participants between 44 and 45 years of age.We examine the association of IGF-1 with social position measured by father's or own occupational class at three time points in childhood and adulthood, in a cohort of individuals born in one month in 1958 (N = 3,374 men and 3,302 women).Lower IGF-1 levels were associated with lower social position measured with father's occupational class at birth (p < 0.0001) and own occupational class aged 42 years (p < 0.001). Adult social position was associated with IGF-1 independently of social position at birth (p < 0.001) or any covariates examined.IGF-1 secretion is associated with social position such that low social position is associated with lower levels of IGF-1. This biomarker may play a role in the development of social differences in morbidities associated with aging, such as the development of disability." @default.
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- W2000255604 date "2008-08-01" @default.
- W2000255604 modified "2023-10-16" @default.
- W2000255604 title "Social Differences in Insulin-like Growth Factor-1: Findings from a British Birth Cohort" @default.
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- W2000255604 doi "https://doi.org/10.1016/j.annepidem.2008.03.001" @default.
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