FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000257810> ?p ?o ?g. }

• W2000257810 endingPage "1230" @default.
• W2000257810 startingPage "1223" @default.
• W2000257810 abstract "Low doses of environmental allergens have been proposed to increase bronchial hyperreactivity in sensitised individuals, without causing immediate asthmatic reactions. The primary aim of the present study was to evaluate whether repeated low doses of allergen, that do not cause overt bronchoconstriction, cause augmented non-specific bronchial reactivity. A secondary aim was to evaluate whether any changes in reactivity are associated with increased variability of lung function, and whether signs of inflammatory activity could be found. To do this, mild asthmatic patients without regular symptoms, but with both immediate and late reactions in response to a high dose of inhaled cat allergen extract, were included in a double blind, placebo controlled, cross-over study in which a low dose of allergen was administered on four consecutive days (Monday to Thursday). The dose of allergen was individualised for each patient, and was calculated to be 25% of the total dose given to produce an immediate and late response at screening. Repeated low dose allergen exposure produced a significant increase in methacholine reactivity compared to placebo, whereas FEV1 in the morning did not significantly change during the allergen week. Each low dose allergen exposure caused small changes in FEV1 (approximately 7% drop), which was significant vs. placebo only on day 2 (Tuesday). During the allergen week, six of eight patients reported asthma symptoms on at least one occasion, and variability in lung function, measured with a portable spirometer, was increased. Repeated low doses of allergen also produced a significant increase of P-ECP vs. placebo, without a significant rise in circulating eosinophils. However, no significant changes in circulating CD3, CD4, CD8, CD19, or CD25 cells were found, evaluated by FACS analysis. We conclude that low doses of allergen produce signs of a mild exacerbation of asthma, including increased bronchial reactivity to methacholine. This clinical model may be useful to evaluate both the pathophysiological mechanisms of asthma, and the effects of novel anti-asthma drugs." @default.
• W2000257810 created "2016-06-24" @default.
• W2000257810 creator A5001571542 @default.
• W2000257810 creator A5021246152 @default.
• W2000257810 creator A5037420565 @default.
• W2000257810 creator A5063855542 @default.
• W2000257810 creator A5078405168 @default.
• W2000257810 creator A5084137985 @default.
• W2000257810 date "1998-10-01" @default.
• W2000257810 modified "2023-10-17" @default.
• W2000257810 title "Mild experimental exacerbation of asthma induced by individualised low-dose repeated allergen exposure. A double-blind evaluation" @default.
• W2000257810 cites W1931895353 @default.
• W2000257810 cites W1975790353 @default.
• W2000257810 cites W1983413329 @default.
• W2000257810 cites W1992999867 @default.
• W2000257810 cites W1996828916 @default.
• W2000257810 cites W2001728531 @default.
• W2000257810 cites W2004633858 @default.
• W2000257810 cites W2004841690 @default.
• W2000257810 cites W2016867245 @default.
• W2000257810 cites W2018958630 @default.
• W2000257810 cites W2030156746 @default.
• W2000257810 cites W2043056769 @default.
• W2000257810 cites W2049239278 @default.
• W2000257810 cites W2049386080 @default.
• W2000257810 cites W2063153627 @default.
• W2000257810 cites W2068582360 @default.
• W2000257810 cites W2071199365 @default.
• W2000257810 cites W2072529555 @default.
• W2000257810 cites W2080529843 @default.
• W2000257810 cites W2092661479 @default.
• W2000257810 cites W2113807290 @default.
• W2000257810 cites W2114518763 @default.
• W2000257810 cites W2125112868 @default.
• W2000257810 cites W2149725533 @default.
• W2000257810 cites W2158113676 @default.
• W2000257810 cites W2312870247 @default.
• W2000257810 cites W2323426201 @default.
• W2000257810 doi "https://doi.org/10.1016/s0954-6111(98)90425-5" @default.
• W2000257810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9926153" @default.
• W2000257810 hasPublicationYear "1998" @default.
• W2000257810 type Work @default.
• W2000257810 sameAs 2000257810 @default.
• W2000257810 citedByCount "23" @default.
• W2000257810 countsByYear W20002578102012 @default.
• W2000257810 countsByYear W20002578102013 @default.
• W2000257810 countsByYear W20002578102015 @default.
• W2000257810 countsByYear W20002578102018 @default.
• W2000257810 countsByYear W20002578102021 @default.
• W2000257810 countsByYear W20002578102022 @default.
• W2000257810 crossrefType "journal-article" @default.
• W2000257810 hasAuthorship W2000257810A5001571542 @default.
• W2000257810 hasAuthorship W2000257810A5021246152 @default.
• W2000257810 hasAuthorship W2000257810A5037420565 @default.
• W2000257810 hasAuthorship W2000257810A5063855542 @default.
• W2000257810 hasAuthorship W2000257810A5078405168 @default.
• W2000257810 hasAuthorship W2000257810A5084137985 @default.
• W2000257810 hasBestOaLocation W20002578101 @default.
• W2000257810 hasConcept C110586980 @default.
• W2000257810 hasConcept C126322002 @default.
• W2000257810 hasConcept C142724271 @default.
• W2000257810 hasConcept C203014093 @default.
• W2000257810 hasConcept C204787440 @default.
• W2000257810 hasConcept C207480886 @default.
• W2000257810 hasConcept C27081682 @default.
• W2000257810 hasConcept C2776042228 @default.
• W2000257810 hasConcept C2776178081 @default.
• W2000257810 hasConcept C2776954882 @default.
• W2000257810 hasConcept C2777014857 @default.
• W2000257810 hasConcept C2777394947 @default.
• W2000257810 hasConcept C2777714996 @default.
• W2000257810 hasConcept C2780333948 @default.
• W2000257810 hasConcept C2780510475 @default.
• W2000257810 hasConcept C2780769369 @default.
• W2000257810 hasConcept C2781260171 @default.
• W2000257810 hasConcept C42219234 @default.
• W2000257810 hasConcept C71924100 @default.
• W2000257810 hasConcept C75603125 @default.
• W2000257810 hasConceptScore W2000257810C110586980 @default.
• W2000257810 hasConceptScore W2000257810C126322002 @default.
• W2000257810 hasConceptScore W2000257810C142724271 @default.
• W2000257810 hasConceptScore W2000257810C203014093 @default.
• W2000257810 hasConceptScore W2000257810C204787440 @default.
• W2000257810 hasConceptScore W2000257810C207480886 @default.
• W2000257810 hasConceptScore W2000257810C27081682 @default.
• W2000257810 hasConceptScore W2000257810C2776042228 @default.
• W2000257810 hasConceptScore W2000257810C2776178081 @default.
• W2000257810 hasConceptScore W2000257810C2776954882 @default.
• W2000257810 hasConceptScore W2000257810C2777014857 @default.
• W2000257810 hasConceptScore W2000257810C2777394947 @default.
• W2000257810 hasConceptScore W2000257810C2777714996 @default.
• W2000257810 hasConceptScore W2000257810C2780333948 @default.
• W2000257810 hasConceptScore W2000257810C2780510475 @default.
• W2000257810 hasConceptScore W2000257810C2780769369 @default.
• W2000257810 hasConceptScore W2000257810C2781260171 @default.
• W2000257810 hasConceptScore W2000257810C42219234 @default.
• W2000257810 hasConceptScore W2000257810C71924100 @default.
• W2000257810 hasConceptScore W2000257810C75603125 @default.

• next