Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000258502> ?p ?o ?g. }
- W2000258502 endingPage "352" @default.
- W2000258502 startingPage "338" @default.
- W2000258502 abstract "Brain connectivity at rest is altered in temporal lobe epilepsy (TLE), particularly in hub areas such as the posterior default mode network (DMN). Although both functional and anatomical connectivity are disturbed in TLE, the relationships between measures as well as to seizure frequency remain unclear. We aim to clarify these associations using connectivity measures specifically sensitive to hubs.Connectivity between 1000 cortical surface parcels was determined in 49 TLE patients and 23 controls with diffusion and resting-state functional magnetic resonance imaging. Two types of hub connectivity were investigated across multiple brain modules (the DMN, motor system, etcetera): (1) within-module connectivity (a measure of local importance that assesses a parcel's communication level within its own subnetwork) and (2) between-module connectivity (a measure that assesses connections across multiple modules).In TLE patients, there was lower overall functional integrity of the DMN as well as an increase in posterior hub connections with other modules. Anatomical between-module connectivity was globally decreased. Higher DMN disintegration (DD) coincided with higher anatomical between-module connectivity, whereas both were associated with increased seizure frequency. DD related to seizure frequency through mediating effects of anatomical connectivity, but seizure frequency also correlated with anatomical connectivity through DD, indicating a complex interaction between multimodal networks and symptoms.We provide evidence for dissociated anatomical and functional hub connectivity in TLE. Moreover, shifts in functional hub connections from within to outside the DMN, an overall loss of integrative anatomical communication, and the interaction between the two increase seizure frequency." @default.
- W2000258502 created "2016-06-24" @default.
- W2000258502 creator A5016203738 @default.
- W2000258502 creator A5020315656 @default.
- W2000258502 creator A5033536755 @default.
- W2000258502 creator A5037129350 @default.
- W2000258502 creator A5061226868 @default.
- W2000258502 creator A5077601092 @default.
- W2000258502 creator A5090414948 @default.
- W2000258502 date "2015-02-25" @default.
- W2000258502 modified "2023-09-29" @default.
- W2000258502 title "Dissociated multimodal hubs and seizures in temporal lobe epilepsy" @default.
- W2000258502 cites W1802209367 @default.
- W2000258502 cites W1967695195 @default.
- W2000258502 cites W1970699942 @default.
- W2000258502 cites W1975008523 @default.
- W2000258502 cites W1983345514 @default.
- W2000258502 cites W1987464027 @default.
- W2000258502 cites W1987869189 @default.
- W2000258502 cites W1987924998 @default.
- W2000258502 cites W1993653829 @default.
- W2000258502 cites W2005172084 @default.
- W2000258502 cites W2006096283 @default.
- W2000258502 cites W2006312249 @default.
- W2000258502 cites W2009208554 @default.
- W2000258502 cites W2017987256 @default.
- W2000258502 cites W2021653459 @default.
- W2000258502 cites W2021947606 @default.
- W2000258502 cites W2022381144 @default.
- W2000258502 cites W2022671987 @default.
- W2000258502 cites W2022806167 @default.
- W2000258502 cites W2036587077 @default.
- W2000258502 cites W2037902675 @default.
- W2000258502 cites W2038068904 @default.
- W2000258502 cites W2038702827 @default.
- W2000258502 cites W2046042924 @default.
- W2000258502 cites W2046349751 @default.
- W2000258502 cites W2046870216 @default.
- W2000258502 cites W2056081184 @default.
- W2000258502 cites W2060694449 @default.
- W2000258502 cites W2061099285 @default.
- W2000258502 cites W2062661436 @default.
- W2000258502 cites W2067456724 @default.
- W2000258502 cites W2078447335 @default.
- W2000258502 cites W2079107720 @default.
- W2000258502 cites W2082316745 @default.
- W2000258502 cites W2085382422 @default.
- W2000258502 cites W2087763077 @default.
- W2000258502 cites W2088905367 @default.
- W2000258502 cites W2089970918 @default.
- W2000258502 cites W2090448039 @default.
- W2000258502 cites W2094292488 @default.
- W2000258502 cites W2101135654 @default.
- W2000258502 cites W2105504969 @default.
- W2000258502 cites W2107566823 @default.
- W2000258502 cites W2110065044 @default.
- W2000258502 cites W2120546516 @default.
- W2000258502 cites W2126650951 @default.
- W2000258502 cites W2130472282 @default.
- W2000258502 cites W2131055855 @default.
- W2000258502 cites W2131494589 @default.
- W2000258502 cites W2131636205 @default.
- W2000258502 cites W2131705496 @default.
- W2000258502 cites W2132175842 @default.
- W2000258502 cites W2134739388 @default.
- W2000258502 cites W2136874658 @default.
- W2000258502 cites W2144827143 @default.
- W2000258502 cites W2151130155 @default.
- W2000258502 cites W2151720121 @default.
- W2000258502 cites W2154600934 @default.
- W2000258502 cites W2157315491 @default.
- W2000258502 cites W2159496596 @default.
- W2000258502 cites W2159549823 @default.
- W2000258502 cites W2164262344 @default.
- W2000258502 cites W2165985389 @default.
- W2000258502 cites W2167822639 @default.
- W2000258502 cites W2170596158 @default.
- W2000258502 cites W4295750005 @default.
- W2000258502 doi "https://doi.org/10.1002/acn3.173" @default.
- W2000258502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4402080" @default.
- W2000258502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25909080" @default.
- W2000258502 hasPublicationYear "2015" @default.
- W2000258502 type Work @default.
- W2000258502 sameAs 2000258502 @default.
- W2000258502 citedByCount "21" @default.
- W2000258502 countsByYear W20002585022015 @default.
- W2000258502 countsByYear W20002585022016 @default.
- W2000258502 countsByYear W20002585022017 @default.
- W2000258502 countsByYear W20002585022018 @default.
- W2000258502 countsByYear W20002585022019 @default.
- W2000258502 countsByYear W20002585022020 @default.
- W2000258502 countsByYear W20002585022021 @default.
- W2000258502 countsByYear W20002585022022 @default.
- W2000258502 countsByYear W20002585022023 @default.
- W2000258502 crossrefType "journal-article" @default.
- W2000258502 hasAuthorship W2000258502A5016203738 @default.
- W2000258502 hasAuthorship W2000258502A5020315656 @default.
- W2000258502 hasAuthorship W2000258502A5033536755 @default.