Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000259660> ?p ?o ?g. }
- W2000259660 endingPage "360" @default.
- W2000259660 startingPage "348" @default.
- W2000259660 abstract "The Pharmaceutical industry is increasingly utilizing amorphous technologies to overcome solubility challenges. A common approach is the use of drug in polymer dispersions to prevent recrystallization of the amorphous drug. Understanding the factors affecting chemical and physical degradation of the drug within these complex systems, e.g., temperature and relative humidity, is an important step in the selection of a lead formulation, and development of appropriate packaging/storage control strategies. The Arrhenius equation has been used as the basis of a number of models to predict the chemical stability of formulated product. In this work, we investigate the increase in chemical degradation seen for one particular spray dried dispersion formulation using hydroxypropyl methylcellulose acetate succinate (HPMC-AS). Samples, prepared using polymers with different substitution levels, were placed on storage for 6 months under a range of different temperature and relative humidity conditions and the degradant level monitored using high-performance liquid chromatography (HPLC). While the data clearly illustrates the impact of temperature and relative humidity on the degradant levels detected, it also highlighted that these terms do not account for all the variability in the data. An extension of the Arrhenius equation to include a term for the polymer chemistry, specifically the degree of succinoyl substitution on the polymer backbone, was shown to improve the fit of the model to the data." @default.
- W2000259660 created "2016-06-24" @default.
- W2000259660 creator A5040666161 @default.
- W2000259660 creator A5044063578 @default.
- W2000259660 creator A5050437774 @default.
- W2000259660 creator A5064673776 @default.
- W2000259660 creator A5066388393 @default.
- W2000259660 creator A5085765854 @default.
- W2000259660 creator A5091444141 @default.
- W2000259660 date "2015-01-01" @default.
- W2000259660 modified "2023-09-27" @default.
- W2000259660 title "Modelling drug degradation in a spray dried polymer dispersion using a modified Arrhenius equation" @default.
- W2000259660 cites W1590254871 @default.
- W2000259660 cites W1970767638 @default.
- W2000259660 cites W1978298690 @default.
- W2000259660 cites W1978360146 @default.
- W2000259660 cites W1983483344 @default.
- W2000259660 cites W1995759327 @default.
- W2000259660 cites W1996785333 @default.
- W2000259660 cites W1998647396 @default.
- W2000259660 cites W1999977692 @default.
- W2000259660 cites W2005816736 @default.
- W2000259660 cites W2009413151 @default.
- W2000259660 cites W2009938495 @default.
- W2000259660 cites W2011947404 @default.
- W2000259660 cites W2013155776 @default.
- W2000259660 cites W2014879978 @default.
- W2000259660 cites W2015433865 @default.
- W2000259660 cites W2015633580 @default.
- W2000259660 cites W2029846748 @default.
- W2000259660 cites W2040432233 @default.
- W2000259660 cites W2041517295 @default.
- W2000259660 cites W2046027112 @default.
- W2000259660 cites W2056434768 @default.
- W2000259660 cites W2056853058 @default.
- W2000259660 cites W2056995570 @default.
- W2000259660 cites W2060137844 @default.
- W2000259660 cites W2062593306 @default.
- W2000259660 cites W2066935923 @default.
- W2000259660 cites W2070701021 @default.
- W2000259660 cites W2073776376 @default.
- W2000259660 cites W2075179133 @default.
- W2000259660 cites W2081217644 @default.
- W2000259660 cites W2082203116 @default.
- W2000259660 cites W2087659180 @default.
- W2000259660 cites W2089828431 @default.
- W2000259660 cites W2094040430 @default.
- W2000259660 cites W2105448626 @default.
- W2000259660 cites W2114263081 @default.
- W2000259660 cites W2126209235 @default.
- W2000259660 cites W2129240970 @default.
- W2000259660 cites W2169796533 @default.
- W2000259660 doi "https://doi.org/10.1016/j.ijpharm.2014.11.063" @default.
- W2000259660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25450477" @default.
- W2000259660 hasPublicationYear "2015" @default.
- W2000259660 type Work @default.
- W2000259660 sameAs 2000259660 @default.
- W2000259660 citedByCount "12" @default.
- W2000259660 countsByYear W20002596602016 @default.
- W2000259660 countsByYear W20002596602017 @default.
- W2000259660 countsByYear W20002596602018 @default.
- W2000259660 countsByYear W20002596602020 @default.
- W2000259660 countsByYear W20002596602021 @default.
- W2000259660 countsByYear W20002596602023 @default.
- W2000259660 crossrefType "journal-article" @default.
- W2000259660 hasAuthorship W2000259660A5040666161 @default.
- W2000259660 hasAuthorship W2000259660A5044063578 @default.
- W2000259660 hasAuthorship W2000259660A5050437774 @default.
- W2000259660 hasAuthorship W2000259660A5064673776 @default.
- W2000259660 hasAuthorship W2000259660A5066388393 @default.
- W2000259660 hasAuthorship W2000259660A5085765854 @default.
- W2000259660 hasAuthorship W2000259660A5091444141 @default.
- W2000259660 hasConcept C120665830 @default.
- W2000259660 hasConcept C121332964 @default.
- W2000259660 hasConcept C127413603 @default.
- W2000259660 hasConcept C151420433 @default.
- W2000259660 hasConcept C151730666 @default.
- W2000259660 hasConcept C155574463 @default.
- W2000259660 hasConcept C158960510 @default.
- W2000259660 hasConcept C177562468 @default.
- W2000259660 hasConcept C178790620 @default.
- W2000259660 hasConcept C185592680 @default.
- W2000259660 hasConcept C186399102 @default.
- W2000259660 hasConcept C192562407 @default.
- W2000259660 hasConcept C195702682 @default.
- W2000259660 hasConcept C2779587474 @default.
- W2000259660 hasConcept C2779679103 @default.
- W2000259660 hasConcept C41008148 @default.
- W2000259660 hasConcept C42360764 @default.
- W2000259660 hasConcept C43617362 @default.
- W2000259660 hasConcept C521977710 @default.
- W2000259660 hasConcept C56052488 @default.
- W2000259660 hasConcept C76155785 @default.
- W2000259660 hasConcept C77281830 @default.
- W2000259660 hasConcept C86183883 @default.
- W2000259660 hasConcept C86803240 @default.
- W2000259660 hasConcept C95121573 @default.
- W2000259660 hasConcept C97355855 @default.