FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000259723> ?p ?o ?g. }

• W2000259723 endingPage "369" @default.
• W2000259723 startingPage "357" @default.
• W2000259723 abstract "Knowledge about the noradrenergic system in birds is very scarce even though their biological diversity and complex social behavior make them an excellent model for studying neuronal functions and developmental biology. While the role of norepinephrine has been described in depth in a large number of central and peripheral functions in mammals, reports for avian species are limited. The radioligand [(3)H]RX 821002 ([(3)H]1,4-[6,7(n)3H]-benzodioxan-2-methoxy-2-yl)-2-imidazol) has been used to map and characterize alpha(2)-adrenoceptors through the chicken brain using in vitro autoradiography and membrane homogenates binding assays. [(3)H]RX 821002 showed a saturable and high affinity binding to a site compatible with alpha(2)-adrenoceptor, and to a serotonergic component. The autoradiographic assays displayed a similar alpha(2)-adrenoceptor distribution than those previously reported in birds using other radioligands such as [(3)H]UK 14304 ([(3)H]5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine) or [(3)H]clonidine. [(3)H]RX 821002 binding pharmacological characterization was carried out in different chicken brain regions using membrane homogenates for competition assays with different alpha(2)-adrenoceptor agonists and antagonists drugs (oxymetazoline, BRL 44408 [2-(2H-(1-methyl-1,3-dihydroisoindole)methyl)-4,5-dihydroimidazole] ARC 239 [2-(2-4-(O-methoxyphenyl)-piperazin-1-yl)-ethyl-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione], prazosin, UK 14304 and RX 821002). The results showed alpha(2A) as the predominant alpha(2)-adrenoceptor subtype in the chicken brain while alpha(2B)- and/or alpha(2C)-adrenoceptor subtypes were detected only in the telencephalon. RX 821002, serotonin (5-HT) and 8-OH-DPAT [8-hydroxy-2-(di-n-propylamino)tetralin] competition assays, and competition binding assays performed in the presence of serotonin demonstrated that [(3)H]RX 821002 binds with higher affinity to a serotonergic component, probably 5-HT(1A) receptors, than to the alpha(2)-adrenoceptors. Similar pharmacological properties for the alpha(2)-adrenoceptor component were observed both in rat and chicken brain. The results demonstrate that the different alpha(2)-adrenoceptor subtypes are present in chicken brain and suggest that these receptors are highly conserved through evolution." @default.
• W2000259723 created "2016-06-24" @default.
• W2000259723 creator A5022005952 @default.
• W2000259723 creator A5024198476 @default.
• W2000259723 creator A5052161973 @default.
• W2000259723 creator A5063642220 @default.
• W2000259723 creator A5083352205 @default.
• W2000259723 date "2006-01-01" @default.
• W2000259723 modified "2023-10-18" @default.
• W2000259723 title "Pharmacological characterization and autoradiographic distribution of α2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain" @default.
• W2000259723 cites W105748703 @default.
• W2000259723 cites W1480852888 @default.
• W2000259723 cites W150624845 @default.
• W2000259723 cites W1511301017 @default.
• W2000259723 cites W1570447560 @default.
• W2000259723 cites W1720110446 @default.
• W2000259723 cites W1978545778 @default.
• W2000259723 cites W1982432849 @default.
• W2000259723 cites W1982735049 @default.
• W2000259723 cites W1985883097 @default.
• W2000259723 cites W1986647402 @default.
• W2000259723 cites W1991650669 @default.
• W2000259723 cites W1992450062 @default.
• W2000259723 cites W1997126353 @default.
• W2000259723 cites W2001287697 @default.
• W2000259723 cites W2005466262 @default.
• W2000259723 cites W2006490359 @default.
• W2000259723 cites W2006875910 @default.
• W2000259723 cites W2007329468 @default.
• W2000259723 cites W2014321807 @default.
• W2000259723 cites W2019887236 @default.
• W2000259723 cites W2019890779 @default.
• W2000259723 cites W2022160743 @default.
• W2000259723 cites W2025696507 @default.
• W2000259723 cites W2026339798 @default.
• W2000259723 cites W2027049600 @default.
• W2000259723 cites W2032996897 @default.
• W2000259723 cites W2038163667 @default.
• W2000259723 cites W2038771053 @default.
• W2000259723 cites W2039765778 @default.
• W2000259723 cites W2043813981 @default.
• W2000259723 cites W2053740633 @default.
• W2000259723 cites W2054381874 @default.
• W2000259723 cites W2054823383 @default.
• W2000259723 cites W2056825647 @default.
• W2000259723 cites W2067232492 @default.
• W2000259723 cites W2069177330 @default.
• W2000259723 cites W2077916586 @default.
• W2000259723 cites W2079634519 @default.
• W2000259723 cites W2081124775 @default.
• W2000259723 cites W2084837813 @default.
• W2000259723 cites W2093686860 @default.
• W2000259723 cites W2098690683 @default.
• W2000259723 cites W2105303099 @default.
• W2000259723 cites W2107329724 @default.
• W2000259723 cites W2109770157 @default.
• W2000259723 cites W2120932814 @default.
• W2000259723 cites W2130025355 @default.
• W2000259723 cites W2137001862 @default.
• W2000259723 cites W2158109323 @default.
• W2000259723 cites W2163815564 @default.
• W2000259723 cites W2167152746 @default.
• W2000259723 cites W2167274840 @default.
• W2000259723 cites W2173726217 @default.
• W2000259723 cites W2223333252 @default.
• W2000259723 cites W2244149931 @default.
• W2000259723 cites W2256339756 @default.
• W2000259723 cites W2268916690 @default.
• W2000259723 cites W2303408262 @default.
• W2000259723 cites W2309929517 @default.
• W2000259723 cites W2345691521 @default.
• W2000259723 cites W2949552926 @default.
• W2000259723 cites W649903757 @default.
• W2000259723 doi "https://doi.org/10.1016/j.neuroscience.2006.03.025" @default.
• W2000259723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16697114" @default.
• W2000259723 hasPublicationYear "2006" @default.
• W2000259723 type Work @default.
• W2000259723 sameAs 2000259723 @default.
• W2000259723 citedByCount "13" @default.
• W2000259723 countsByYear W20002597232013 @default.
• W2000259723 countsByYear W20002597232015 @default.
• W2000259723 countsByYear W20002597232016 @default.
• W2000259723 countsByYear W20002597232017 @default.
• W2000259723 crossrefType "journal-article" @default.
• W2000259723 hasAuthorship W2000259723A5022005952 @default.
• W2000259723 hasAuthorship W2000259723A5024198476 @default.
• W2000259723 hasAuthorship W2000259723A5052161973 @default.
• W2000259723 hasAuthorship W2000259723A5063642220 @default.
• W2000259723 hasAuthorship W2000259723A5083352205 @default.
• W2000259723 hasConcept C107824862 @default.
• W2000259723 hasConcept C126322002 @default.
• W2000259723 hasConcept C134018914 @default.
• W2000259723 hasConcept C15744967 @default.
• W2000259723 hasConcept C170493617 @default.
• W2000259723 hasConcept C171606756 @default.
• W2000259723 hasConcept C185592680 @default.
• W2000259723 hasConcept C2775864247 @default.
• W2000259723 hasConcept C2776504411 @default.

• next