Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000261005> ?p ?o ?g. }
- W2000261005 endingPage "473" @default.
- W2000261005 startingPage "461" @default.
- W2000261005 abstract "DNA methylation-dependent gene silencing, mediated by DNA methyltransferases (DNMTs), is essential for normal mammalian development and its dysregulation has been implicated in neurodevelopmental disorders. Despite this, little is known about DNMTs in the developing or mature nervous system. Here, we show that DNMT1, 3a and 3b are expressed at discrete developmental stages in the olfactory neuron lineage, coincident with key shifts in developmental gene expression. DNMT1 is induced in cycling progenitors and is retained in post-mitotic olfactory receptor neurons (ORNs). DNMT3b is restricted to mitotic olfactory progenitors, whereas DNMT3a is expressed only in post-mitotic immature neurons prior to ORN terminal maturation, coincident with histone deacetylase 2 (HDAC2), a key downstream effector of methylation-dependent chromatin condensation. Similar stage-specific expression of DNMT3b and 3a was also found in other developing sensory and CNS neurons. This suggests that progressive lineage restriction regulated by methylation-dependent silencing could be a highly conserved mechanism shared by multiple lineages in the developing nervous system." @default.
- W2000261005 created "2016-06-24" @default.
- W2000261005 creator A5028315317 @default.
- W2000261005 creator A5033164569 @default.
- W2000261005 creator A5090758782 @default.
- W2000261005 date "2005-12-01" @default.
- W2000261005 modified "2023-10-18" @default.
- W2000261005 title "Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development" @default.
- W2000261005 cites W1504303645 @default.
- W2000261005 cites W1508625050 @default.
- W2000261005 cites W1544893850 @default.
- W2000261005 cites W1559742681 @default.
- W2000261005 cites W1577875429 @default.
- W2000261005 cites W1652583010 @default.
- W2000261005 cites W1765469392 @default.
- W2000261005 cites W1793673261 @default.
- W2000261005 cites W1912063668 @default.
- W2000261005 cites W1966410619 @default.
- W2000261005 cites W1966511088 @default.
- W2000261005 cites W1966792643 @default.
- W2000261005 cites W1967064280 @default.
- W2000261005 cites W1968597070 @default.
- W2000261005 cites W1975900900 @default.
- W2000261005 cites W1981537755 @default.
- W2000261005 cites W1981811514 @default.
- W2000261005 cites W1982273994 @default.
- W2000261005 cites W1982356313 @default.
- W2000261005 cites W1987587605 @default.
- W2000261005 cites W1988816781 @default.
- W2000261005 cites W2000313340 @default.
- W2000261005 cites W2004715908 @default.
- W2000261005 cites W2004836530 @default.
- W2000261005 cites W2011221870 @default.
- W2000261005 cites W2013655994 @default.
- W2000261005 cites W2013920501 @default.
- W2000261005 cites W2017285299 @default.
- W2000261005 cites W2035939797 @default.
- W2000261005 cites W2038439057 @default.
- W2000261005 cites W2041674913 @default.
- W2000261005 cites W2046241907 @default.
- W2000261005 cites W2046244011 @default.
- W2000261005 cites W2047680737 @default.
- W2000261005 cites W2050648377 @default.
- W2000261005 cites W2056521900 @default.
- W2000261005 cites W2057658774 @default.
- W2000261005 cites W2060446375 @default.
- W2000261005 cites W2066679122 @default.
- W2000261005 cites W2068407791 @default.
- W2000261005 cites W2070484728 @default.
- W2000261005 cites W2072248036 @default.
- W2000261005 cites W2073157961 @default.
- W2000261005 cites W2074264906 @default.
- W2000261005 cites W2078833131 @default.
- W2000261005 cites W2081946757 @default.
- W2000261005 cites W2084390009 @default.
- W2000261005 cites W2084930040 @default.
- W2000261005 cites W2087588672 @default.
- W2000261005 cites W2101344684 @default.
- W2000261005 cites W2106622947 @default.
- W2000261005 cites W2107005658 @default.
- W2000261005 cites W2107038650 @default.
- W2000261005 cites W2110636775 @default.
- W2000261005 cites W2116465810 @default.
- W2000261005 cites W2121417064 @default.
- W2000261005 cites W2127311839 @default.
- W2000261005 cites W2136791900 @default.
- W2000261005 cites W2145975061 @default.
- W2000261005 cites W2146915584 @default.
- W2000261005 cites W2147029479 @default.
- W2000261005 cites W2149790281 @default.
- W2000261005 cites W2149858761 @default.
- W2000261005 cites W2157156910 @default.
- W2000261005 cites W2165372186 @default.
- W2000261005 cites W2166673891 @default.
- W2000261005 cites W2187482679 @default.
- W2000261005 cites W4378718562 @default.
- W2000261005 cites W962147124 @default.
- W2000261005 doi "https://doi.org/10.1016/j.ydbio.2005.09.048" @default.
- W2000261005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16288735" @default.
- W2000261005 hasPublicationYear "2005" @default.
- W2000261005 type Work @default.
- W2000261005 sameAs 2000261005 @default.
- W2000261005 citedByCount "47" @default.
- W2000261005 countsByYear W20002610052012 @default.
- W2000261005 countsByYear W20002610052013 @default.
- W2000261005 countsByYear W20002610052014 @default.
- W2000261005 countsByYear W20002610052015 @default.
- W2000261005 countsByYear W20002610052016 @default.
- W2000261005 countsByYear W20002610052017 @default.
- W2000261005 countsByYear W20002610052018 @default.
- W2000261005 countsByYear W20002610052019 @default.
- W2000261005 countsByYear W20002610052021 @default.
- W2000261005 countsByYear W20002610052022 @default.
- W2000261005 crossrefType "journal-article" @default.
- W2000261005 hasAuthorship W2000261005A5028315317 @default.
- W2000261005 hasAuthorship W2000261005A5033164569 @default.
- W2000261005 hasAuthorship W2000261005A5090758782 @default.
- W2000261005 hasConcept C104317684 @default.