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- W2000261325 abstract "The interactions between ouabain and sarcolemmal-bound Na+, K+-ATPase activity have been studied in rat left ventricles 70–130% hypertrophied by aortic constriction. Isolated sarcolemmal vesicles were 75-fold enriched in Na+, K+-ATPase and consisted in both impermeable inside-out vesicles and leaky material. The enzymatic activity was found to be almost completely inhibited at 10−6 M ouabain instead of 2 × 10−4 M in the normal left ventricle. In contrast with normal heart in which a Ca2+-free perfusion revealed a Na+, K+-ATPase activity highly sensitive to ouabain, in hypertrophied heart, a pretreatment plus or minus Ca2+ did not affect the high sensitivity form (half maximum inhibition with 0·8−2·2 × 10−9M ouabain). This enzyme form differed from the usual Na+, K+-ATPase activities by the absence of any detectable ouabain/K+ antagonism. The levels of 3H-ouabain binding, however, did not correlate with the levels of Na+, K+-ATPase inhibition. These results suggested that the Na+, K+-ATPase—ouabain interactions were altered in hypertrophied rat heart." @default.
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- W2000261325 date "1984-12-02" @default.
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- W2000261325 title "Hypertrophied rat heart. New Na+, K+-ATPaseouabain interactions in sarcolemma vesicles" @default.
- W2000261325 doi "https://doi.org/10.1093/eurheartj/5.suppl_f.315" @default.
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