Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000261355> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2000261355 endingPage "529" @default.
- W2000261355 startingPage "519" @default.
- W2000261355 abstract "The formyl peptide receptor gene family encodes G protein-coupled receptors for phagocyte chemoattractants, including bacteria- and mitochondria-derived N-formylpeptides. The human family has 3 functional genes, whereas the mouse family has 7 functional genes and 2 possible pseudogenes (ΨFpr-rs2 and ΨFpr-rs3). Here we characterize ΨFpr-rs2, a duplication of Fpr-rs2. Compared to Fpr-rs2, the ΨFpr-rs2 ORF is 186 nucleotides shorter but 98% identical. Due to a deletion and frame shift, the sequences lack homology from amino acid 219-289. Both transcripts were detected constitutively in multiple immune organs; however, ΨFpr-rs2 was consistently less abundant than Fpr-rs2. LPS induced expression of ΨFpr-rs2, but not Fpr-rs2, in spleen and bone marrow. Both transcripts were detected constitutively in thioglycollate-elicited peritoneal neutrophils, whereas only Fpr-rs2 was detected in thioglycollate-elicited peritoneal macrophages. Both transcripts were induced in LPS-stimulated macrophages. ΨFpr-rs2-GFP fusion protein appeared in cytoplasm but not plasma membrane of transfected HEK 293 cells, whereas Fpr-rs2-GFP labeled only plasma membrane. Survival of ΨFpr-rs2(-/-) mice was 33% shorter than that of wild-type and heterozygous littermates (p < 0.05), but no signature pathology was identified. Since ΨFpr-rs2 is expressed in phagocytes and regulated by bacterial products, and may affect longevity, we propose renaming it Fpr-rs8, an atypical member of the formyl peptide receptor gene family." @default.
- W2000261355 created "2016-06-24" @default.
- W2000261355 creator A5003246603 @default.
- W2000261355 creator A5027808252 @default.
- W2000261355 creator A5054434906 @default.
- W2000261355 creator A5068107996 @default.
- W2000261355 creator A5084364506 @default.
- W2000261355 date "2011-01-01" @default.
- W2000261355 modified "2023-10-15" @default.
- W2000261355 title "Characterization of <i>Fpr-rs8</i>, an Atypical Member of the Mouse Formyl Peptide Receptor Gene Family" @default.
- W2000261355 cites W1592678705 @default.
- W2000261355 cites W1966811328 @default.
- W2000261355 cites W2001286841 @default.
- W2000261355 cites W2004189071 @default.
- W2000261355 cites W2006195332 @default.
- W2000261355 cites W2009187090 @default.
- W2000261355 cites W2025946770 @default.
- W2000261355 cites W2045120140 @default.
- W2000261355 cites W2048087356 @default.
- W2000261355 cites W2049662845 @default.
- W2000261355 cites W2050877281 @default.
- W2000261355 cites W2053202566 @default.
- W2000261355 cites W2054895562 @default.
- W2000261355 cites W2079168625 @default.
- W2000261355 cites W2092254747 @default.
- W2000261355 cites W2096116412 @default.
- W2000261355 cites W2119221986 @default.
- W2000261355 cites W2128829928 @default.
- W2000261355 cites W2131896212 @default.
- W2000261355 cites W2138008048 @default.
- W2000261355 cites W2140332898 @default.
- W2000261355 cites W2162382352 @default.
- W2000261355 doi "https://doi.org/10.1159/000327718" @default.
- W2000261355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3186714" @default.
- W2000261355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21691049" @default.
- W2000261355 hasPublicationYear "2011" @default.
- W2000261355 type Work @default.
- W2000261355 sameAs 2000261355 @default.
- W2000261355 citedByCount "11" @default.
- W2000261355 countsByYear W20002613552012 @default.
- W2000261355 countsByYear W20002613552013 @default.
- W2000261355 countsByYear W20002613552014 @default.
- W2000261355 countsByYear W20002613552015 @default.
- W2000261355 countsByYear W20002613552017 @default.
- W2000261355 countsByYear W20002613552020 @default.
- W2000261355 countsByYear W20002613552021 @default.
- W2000261355 crossrefType "journal-article" @default.
- W2000261355 hasAuthorship W2000261355A5003246603 @default.
- W2000261355 hasAuthorship W2000261355A5027808252 @default.
- W2000261355 hasAuthorship W2000261355A5054434906 @default.
- W2000261355 hasAuthorship W2000261355A5068107996 @default.
- W2000261355 hasAuthorship W2000261355A5084364506 @default.
- W2000261355 hasBestOaLocation W20002613551 @default.
- W2000261355 hasConcept C104317684 @default.
- W2000261355 hasConcept C153911025 @default.
- W2000261355 hasConcept C170493617 @default.
- W2000261355 hasConcept C2776731609 @default.
- W2000261355 hasConcept C54166955 @default.
- W2000261355 hasConcept C55493867 @default.
- W2000261355 hasConcept C86803240 @default.
- W2000261355 hasConceptScore W2000261355C104317684 @default.
- W2000261355 hasConceptScore W2000261355C153911025 @default.
- W2000261355 hasConceptScore W2000261355C170493617 @default.
- W2000261355 hasConceptScore W2000261355C2776731609 @default.
- W2000261355 hasConceptScore W2000261355C54166955 @default.
- W2000261355 hasConceptScore W2000261355C55493867 @default.
- W2000261355 hasConceptScore W2000261355C86803240 @default.
- W2000261355 hasIssue "5" @default.
- W2000261355 hasLocation W20002613551 @default.
- W2000261355 hasLocation W20002613552 @default.
- W2000261355 hasLocation W20002613553 @default.
- W2000261355 hasLocation W20002613554 @default.
- W2000261355 hasOpenAccess W2000261355 @default.
- W2000261355 hasPrimaryLocation W20002613551 @default.
- W2000261355 hasRelatedWork W1534683796 @default.
- W2000261355 hasRelatedWork W2009966535 @default.
- W2000261355 hasRelatedWork W2019988726 @default.
- W2000261355 hasRelatedWork W2045322776 @default.
- W2000261355 hasRelatedWork W2054895562 @default.
- W2000261355 hasRelatedWork W2082530227 @default.
- W2000261355 hasRelatedWork W2088063203 @default.
- W2000261355 hasRelatedWork W2088452759 @default.
- W2000261355 hasRelatedWork W2171277769 @default.
- W2000261355 hasRelatedWork W4252629924 @default.
- W2000261355 hasVolume "3" @default.
- W2000261355 isParatext "false" @default.
- W2000261355 isRetracted "false" @default.
- W2000261355 magId "2000261355" @default.
- W2000261355 workType "article" @default.