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• W2000261563 startingPage "11348" @default.
• W2000261563 abstract "The interleukin-2 (IL-2)/IL-2 receptor (IL-2R) system is the main regulatory determinant of T cell reactivity. Although it is well known that IL-2 secretion is impaired during HIV infection, up to now IL-2R expression has not been extensively studied in HIV-infected patients despite the use of IL-2 in clinical therapy trials. We show here that IL-2R expression in HIV patients with high viral load (group 1 in the study) is greatly enhanced on B lymphocytes, CD8 T lymphocytes, and monocytes, but not on CD4 T lymphocytes, compared with noninfected individuals. Paradoxically, this modified IL-2R expression does not lead to increased IL-2 responsiveness, except for B lymphocytes. In patients receiving triple combination therapy (TCT, two reverse transcriptase inhibitors and one protease inhibitor) that has triggered a drastic reduction in plasma viral load and an increase in CD4 counts (group 2 patients), IL-2R expression is significantly lower than in group 1 patients. Moreover, cells involved in cellular immunity and CD4 T lymphocytes have the capacity to respond to IL-2 after TCT. These results allow us to anticipate a beneficial role of IL-2 immunotherapy in combination with TCT." @default.
• W2000261563 created "2016-06-24" @default.
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• W2000261563 date "1998-09-15" @default.
• W2000261563 modified "2023-10-12" @default.
• W2000261563 title "Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy" @default.
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• W2000261563 doi "https://doi.org/10.1073/pnas.95.19.11348" @default.
• W2000261563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/21645" @default.
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