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- W2000261582 abstract "The effects of angiotensin II (AII) and natriuretic peptide (ANP), alone or in combination, on tuberoinfundibular dopaminergic (TIDA) neuronal activity and on serum PRL levels were examined in this study. The TIDA neuronal activity was determined by measuring 3,4-dihydroxyphenylacetic acid (DOPAC) concentration in the median eminence using high-performance liquid chromatography plus electrochemical detection, and serum PRL levels were determined by radioimmunoassay. Intracerebroventricular injection of AII induced both time (5-60 min)- and dose (0.01-1 microg)-dependent effects by stimulating TIDA neuronal activity and inhibiting serum PRL levels in ovariectomized, estrogen-treated rats. ANP in 0.01-10 microg doses, on the other hand, had no significant effect on TIDA neurons, nor on serum PRL at 30 min. When ANP (in 0.1-10 microg doses) was co-administered with AII (1 microg dose), it dose-dependently attenuated the effects of AII on TIDA neuronal activity and on serum PRL levels. In a separate study using single-unit recording of neurons of the dorsomedial arcuate nucleus (dmARC) in brain slices, where most TIDA neurons reside, AII stimulated 68.0% of 72 units recorded. Few (5.6%) units were inhibited and the remaining ones were not responsive. ANP alone was mostly ineffective on dmARC neurons (63.0% of 54 units), and it stimulated and inhibited 22.2 and 14.8% of them, respectively. When ANP was co-administered with AII to AII-responsive units, however, it significantly attenuated the effects of AII in 81.5% of 27 units. Other neurons were unaffected. Thus, results from the in vivo study indicate that ANP can negatively modulate the stimulatory effect of AII on hypothalamic TIDA neurons and the inhibitory effect on serum PRL levels; and the in vitro electrophysiological data substantiates this observation by showing that ANP exerts a similar modulation on dmARC neurons." @default.
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- W2000261582 date "1997-01-01" @default.
- W2000261582 modified "2023-09-23" @default.
- W2000261582 title "Atrial Natriuretic Peptide Negatively Modulates the Stimulatory Effects of Angiotensin II on Tuberoinfundibular Dopaminergic Neuronal Activity" @default.
- W2000261582 doi "https://doi.org/10.1159/000127254" @default.
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