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• W2000262709 abstract "Since the Japanese have not reached the recommended daily allowance (RDA) for calcium (600 mg), milk is recommended as a Ca-rich food to increase Ca intake and prevent osteoporosis in Japan. To determine whether milk consumption influences Ca/bone metabolism in the Ca-deficient population, relationships between milk consumption and serum alkaline phosphatase (Al-P) activity were analyzed in 3,098 premenopausal and 1,182 postmenopausal women and 13,141 men aged 30 to 69 years. Milk consumption was classified into no/yes groups by a self-administered questionnaire that asked Do you drink a glass of milk (180 to 200 mL) or more everyday?. Regardless of age or sex, the yes group had a lower activity of serum Al-P than the no group. Milk consumption decreased the activity to a greater degree in women, especially perimenopausal/postmenopausal women, than in men. These results were confirmed in a multivariate analysis considering age, body mass index (BMI), and smoking and drinking habits as confounding factors. Although menopause obviously increased serum Al-P activity in perimenopausal women, it could not influence the effects of milk consumption on the activity. These results suggest that milk has osteostatic effects on humans via a mechanism different from that of estrogens. Milk consumption, even one glass per day, may be an easy and effective strategy for prevention of osteoporosis in the Ca-deficient population, especially perimenopausal/postmenopausal women." @default.
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• W2000262709 date "1995-09-01" @default.
• W2000262709 modified "2023-10-02" @default.
• W2000262709 title "Milk consumption decreases activity of human serum alkaline phosphatase: A cross-sectional study" @default.
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• W2000262709 doi "https://doi.org/10.1016/0026-0495(95)90014-4" @default.
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