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- W2000262901 abstract "Purpose: The aim of this study was to determine differences in particle size between three prednisolone acetate suspensions: Pred Forte® , EconoPred® Plus, and generic prednisolone acetate 1%. Setting: This study employed the setting of a laboratory evaluation. Methods: Qualitative assessment of sedimentation rate as a function of particle size was the method employed for this study. Samples of the three products were taken from the top of the suspensions at 0 and 6 h and then at 12-h intervals from 12 to 72 h. At 72 h, a sample was pulled from the bottom of each suspension. Results: Particle size in aliquots removed from the top of the suspensions steadily decreased over time. In the Pred Forte® sample, results for 72 h (bottom) were consistent with T = 0 h results. In the generic and EconoPred® Plus lots, the T = 72 h (bottom) results exceeded the T = 0 h results, suggesting a tendency for these particles to agglomerate more readily. Conclusions: The prednisolone particles in Pred Forte® were smaller and more uniform at all time points, allowing them to stay in suspension longer. This may result in greater homogeneity between doses and increased ocular bioavailability." @default.
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- W2000262901 date "2007-04-01" @default.
- W2000262901 modified "2023-10-18" @default.
- W2000262901 title "Comparative Analysis of Prednisolone Acetate Suspensions" @default.
- W2000262901 cites W2032512541 @default.
- W2000262901 cites W2071562760 @default.
- W2000262901 doi "https://doi.org/10.1089/jop.2006.0070" @default.
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