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• W2000262961 endingPage "991" @default.
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• W2000262961 abstract "Purpose To compare region of interest (ROI)-based and diffusion tensor tractography (DTT)-based methods for evaluating diffusion properties of the spinal cord as a function of age. Materials and Methods Commonly, an ROI segmentation is used to delineate the spinal cord. In this work, new segmentation methods are developed based on DTT. In a first, DTT-based, segmentation approach, the diffusion properties are calculated on the tracts. In a second method, the diffusion properties are analyzed in the spinal cord voxels that contain a certain number of tracts. We studied the changes in diffusion properties of the human spinal cord in subjects of different ages. Diffusion tensor imaging (DTI) measurements of the cervical spinal cord were acquired on 42 healthy volunteers (age range = 19–87 years). The fractional anisotropy (FA), the mean diffusivity (MD), and eigenvalues (λ1, λ2, and λ3) were compared for the ROI- and DTT-based segmentation methods. Results Our automatic techniques are shown to be highly reproducible and sensitive for detecting DTI changes. FA decreased (r = –0.38; P < 0.05), whereas MD and eigenvalues increased (r = ± 0.45; P < 0.05) with age. These trends were not statistically significant for the ROI-based segmentation (P > 0.05). Conclusion DTT is a robust and reproducible technique to segment the voxels of interest in the spinal cord. J. Magn. Reson. Imaging 2008;27:978–991. © 2008 Wiley-Liss, Inc." @default.
• W2000262961 created "2016-06-24" @default.
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• W2000262961 date "2008-01-01" @default.
• W2000262961 modified "2023-10-09" @default.
• W2000262961 title "A tracking-based diffusion tensor imaging segmentation method for the detection of diffusion-related changes of the cervical spinal cord with aging" @default.
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• W2000262961 doi "https://doi.org/10.1002/jmri.21338" @default.
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