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- W2000263524 abstract "Ryanodine, a highly toxic alkaloid known to react specifically with the Ca2+ release channels in sarcoplasmic reticulum (SR), was employed to study Ca2+ sequestration in the liver. Ryanodine at a 200 μM concentration increased cytosolic free Ca2+ levels and phosphorylase a activity in isolated hepatocytes. These effects may involve microsomal Ca2+ sequestration, because ryanodine, in the presence of inhibitors of mitochondrial Ca2+ uptake, at concentrations of 1 nM, 1 μM, 50 μM and 100 μM decreased 45Ca2+ retention in permeabilized hepatocytes. This inhibition of Ca2+ retention by ryanodine was not due to inhibition of the microsomal Ca2+-ATPase. Dantrolene, a compound shown previously to inhibit ryanodine binding in the liver, also decreased 45Ca2+ retention in permeabilized hepatocytes, and activated phosphorylase a. These results show that ryanodine administration alters calcium sequestration in liver. The possibility of the existence of a ryanodine-sensitive Ca2+-release channel in liver is discussed." @default.
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- W2000263524 date "1991-10-01" @default.
- W2000263524 modified "2023-10-14" @default.
- W2000263524 title "Effects of ryanodine on calcium sequestration in the rat liver" @default.
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- W2000263524 doi "https://doi.org/10.1016/0006-2952(91)90518-a" @default.
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