Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000264611> ?p ?o ?g. }
- W2000264611 endingPage "695" @default.
- W2000264611 startingPage "686" @default.
- W2000264611 abstract "Behavioral flexibility allows individuals to adapt to situations in which rewards and goals change. Potentially addictive drugs may impair flexible decision-making by altering brain mechanisms that compute reward expectancies, thereby facilitating maladaptive drug use. To investigate this hypothesis, we tested the effects of oxycodone exposure on rats in two complementary learning and memory tasks that engage distinct learning strategies and neural circuits. Rats were trained first in either a spatial or a body-turn discrimination on a radial maze. After initial training, rats were given oxycodone or vehicle injections in their home cages for 5 d. Reversal learning was tested 36 h after the final drug exposure. We hypothesized that if oxycodone impaired behavioral flexibility, then drug-exposed rats should learn reversals more slowly than controls. Oxycodone exposure impaired spatial reversal learning when reward contingencies changed rapidly, but not when they changed slowly. During rapid reversals, oxycodone-exposed rats required more trials to reach criterion, made more perseverative errors, and were more likely to make errors after correct responses than controls. Oxycodone impaired body-turn reversal learning in similar patterns. Limited exposure to oxycodone reduced behavioral flexibility when rats were tested in a drug-free state, suggesting that impaired decision-making is an enduring consequence of oxycodone exposure." @default.
- W2000264611 created "2016-06-24" @default.
- W2000264611 creator A5002903510 @default.
- W2000264611 creator A5080322809 @default.
- W2000264611 date "2014-11-17" @default.
- W2000264611 modified "2023-09-25" @default.
- W2000264611 title "Behavioral flexibility and response selection are impaired after limited exposure to oxycodone" @default.
- W2000264611 cites W143325108 @default.
- W2000264611 cites W1490070004 @default.
- W2000264611 cites W1519532914 @default.
- W2000264611 cites W1523806406 @default.
- W2000264611 cites W1526042634 @default.
- W2000264611 cites W1529892095 @default.
- W2000264611 cites W1556179618 @default.
- W2000264611 cites W170489760 @default.
- W2000264611 cites W1762920573 @default.
- W2000264611 cites W1948130162 @default.
- W2000264611 cites W1956210168 @default.
- W2000264611 cites W1963617441 @default.
- W2000264611 cites W1964952275 @default.
- W2000264611 cites W1970929159 @default.
- W2000264611 cites W1971189295 @default.
- W2000264611 cites W1972559070 @default.
- W2000264611 cites W1975489711 @default.
- W2000264611 cites W1979300762 @default.
- W2000264611 cites W1979455727 @default.
- W2000264611 cites W1981727048 @default.
- W2000264611 cites W1981739486 @default.
- W2000264611 cites W1981891173 @default.
- W2000264611 cites W1982298072 @default.
- W2000264611 cites W1984336157 @default.
- W2000264611 cites W1985276070 @default.
- W2000264611 cites W1985719027 @default.
- W2000264611 cites W1986554537 @default.
- W2000264611 cites W1987020327 @default.
- W2000264611 cites W1988182239 @default.
- W2000264611 cites W1992208327 @default.
- W2000264611 cites W1993230606 @default.
- W2000264611 cites W2003495873 @default.
- W2000264611 cites W2009187750 @default.
- W2000264611 cites W2009530087 @default.
- W2000264611 cites W2009794137 @default.
- W2000264611 cites W2014051345 @default.
- W2000264611 cites W2017966774 @default.
- W2000264611 cites W2020461442 @default.
- W2000264611 cites W2024083302 @default.
- W2000264611 cites W2028270191 @default.
- W2000264611 cites W2031319874 @default.
- W2000264611 cites W2032724628 @default.
- W2000264611 cites W2036922140 @default.
- W2000264611 cites W2039129771 @default.
- W2000264611 cites W2042386124 @default.
- W2000264611 cites W2043392652 @default.
- W2000264611 cites W2044856969 @default.
- W2000264611 cites W2049258678 @default.
- W2000264611 cites W2054695597 @default.
- W2000264611 cites W2054749214 @default.
- W2000264611 cites W2057001461 @default.
- W2000264611 cites W2057726371 @default.
- W2000264611 cites W2065338964 @default.
- W2000264611 cites W2072673971 @default.
- W2000264611 cites W2072800295 @default.
- W2000264611 cites W2075527287 @default.
- W2000264611 cites W2077675607 @default.
- W2000264611 cites W2078370188 @default.
- W2000264611 cites W2083537735 @default.
- W2000264611 cites W2084350789 @default.
- W2000264611 cites W2085090249 @default.
- W2000264611 cites W2085553767 @default.
- W2000264611 cites W2086685521 @default.
- W2000264611 cites W2088445784 @default.
- W2000264611 cites W2092935454 @default.
- W2000264611 cites W2093281873 @default.
- W2000264611 cites W2102027938 @default.
- W2000264611 cites W2102225481 @default.
- W2000264611 cites W2103768739 @default.
- W2000264611 cites W2104047644 @default.
- W2000264611 cites W2104469372 @default.
- W2000264611 cites W2106719141 @default.
- W2000264611 cites W2113690251 @default.
- W2000264611 cites W2114408977 @default.
- W2000264611 cites W2115132834 @default.
- W2000264611 cites W2117130856 @default.
- W2000264611 cites W2117732933 @default.
- W2000264611 cites W2117808207 @default.
- W2000264611 cites W2117948779 @default.
- W2000264611 cites W2120520226 @default.
- W2000264611 cites W2121370521 @default.
- W2000264611 cites W2121584908 @default.
- W2000264611 cites W2129530731 @default.
- W2000264611 cites W2135546946 @default.
- W2000264611 cites W2139053813 @default.
- W2000264611 cites W2148408061 @default.
- W2000264611 cites W2149514160 @default.
- W2000264611 cites W2161014456 @default.
- W2000264611 cites W2164776144 @default.
- W2000264611 cites W2170476476 @default.
- W2000264611 cites W2188872902 @default.