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• W2000264750 abstract "Les pathologies associées à l'usage du tabac sont nombreuses et pour certaines bien connues des médecins et du public, en particulier les cancers des interfaces épithéliales bronchiques, ORL et vésicales, mais d'autres pathologies à composante immunitaire lui sont aussi reliées. Les mécanismes physiopathologiques reliant exposition tabagique et pathologies sont paradoxalement encore mal connus, en particulier ceux concernant le système immunitaire et plus encore ceux mettant en jeu le système immunitaire muqueux. Cet article fait une revue des connaissances actuelles sur ce sujet sensible et de grande importance en Santé publique. Au niveau de l'immunité systémique, l'exposition tabagique induit un déficit immunitaire acquis, au moins partiel, qui peut favoriser le développement de phénomènes d'hypersensibilité et de pathologies auto-immunes. En ce qui concerne le système immunitaire muqueux, l'exposition à la fumée de tabac induit des anomalies acquises de l'immunité innée aussi bien que de l'immunité adaptative, auxquelles s'ajoutent des phénomènes inflammatoires locaux. Tobacco usage induces many pathological disorders, most of them being well known from patients and medical people, particularly neoplasia of mucosal surfaces such as bronchi, ENT, and bladder, but other immune-mediated disorders can be attributed to tobacco smoke exposure. Physiopathological mechanisms remain paradoxically ill-known, particularly the effects on the systemic immune system, and moreover in the mucosal immune system. This paper reviews the knowledge on a major topic for public health. Considering the systemic immune system, tobacco smoke exposure induces an acquired immune deficiency which could induce hypersensitivity or autoimmune pathologies. Concerning the mucosal immune system, tobacco smoke exposure induces as well a local acquired immune deficiency of innate immunity and of adaptative immunity. Local inflammatory phenomena are often associated to produce clinical symptoms." @default.
• W2000264750 created "2016-06-24" @default.
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• W2000264750 date "2004-03-01" @default.
• W2000264750 modified "2023-10-18" @default.
• W2000264750 title "Tabac et immunité muqueuse: Inflammation ou déficit immunitaire acquis" @default.
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• W2000264750 doi "https://doi.org/10.1016/s0338-9898(04)90091-1" @default.
• W2000264750 hasPublicationYear "2004" @default.
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