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- W2000265943 abstract "Urinary excreted RNA and DNA catabolites are used as noninvasive markers for metabolic processes: 8-oxo-2′-deoxyguanosine (8-oxodG) potentially represents oxidative stress to DNA/deoxyribonucleotidetriphosphate pool, modified ribonucleoside pseudouridine (ψ) originating mainly from degraded rRNA and tRNA reflects RNA turnover. Modified amino acid γ-carboxyglutamic acid (Gla) stems from degraded proteins reflecting turnover of proteins. Aim of the present study was to investigate (44 healthy males, 3–18 y) how excretion rates of 8-oxodG, ψ, and Gla are related to resting metabolic rate and energy intake. Excretion rates of 8-oxodG (pmol/kg/d), ψ (μmol/kg/d), and Gla (μmol/kg/d) were significantly correlated with resting metabolic rate (kJ/kg/d): r2 = 0.108 (p = 0.029), 0.691 and 0.552 (p < 0.0001), respectively. Excretion rates of 8-oxodG, ψ, and Gla were also significantly correlated with energy intake (kJ/kg/d): r2 = 0.108 (p = 0.036), 0.602 and 0.462 (p < 0.0001). 8-oxodG and Gla excretion was significantly correlated with ψ excretion: r2 = 0.174 (p = 0.005) and 0.709 (p < 0.0001). These results indicate close relationships between whole-body RNA and protein degradation and metabolic rate. The relationship between 8-oxodG excretion and metabolic rate, however, is less strong suggesting that factors other than metabolic rate considerably affect the oxidative stress to DNA." @default.
- W2000265943 created "2016-06-24" @default.
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- W2000265943 date "2008-09-01" @default.
- W2000265943 modified "2023-10-07" @default.
- W2000265943 title "Noninvasive Markers of Oxidative DNA Stress, RNA Degradation and Protein Degradation Are Differentially Correlated With Resting Metabolic Rate and Energy Intake in Children and Adolescents" @default.
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- W2000265943 doi "https://doi.org/10.1203/pdr.0b013e31817cfca6" @default.
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