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- W2000266593 abstract "Simian Virus 40 (SV40)-encoded large T antigen has an intrinsic ATP-dependent DNA-unwinding activity which is necessary for an early step in the activation of the viral origin of replication. Isolated T antigen unwinds any double-stranded DNA, regardless of whether it is linear or circularly closed. However, initiation of DNA replication depends on an intact origin of replication, and even minor deviations from the wild-type origin sequence abolish the template activity of an origin-bearing plasmid. This discrepancy suggests that T antigen may not be sufficient for origin activation and that other, probably cellular, functions are involved. We have isolated a cellular protein, the LOB protein, which specifically interacts with the AT-rich region of the SV40 origin and which induces a pronounced bending of the bound DNA." @default.
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- W2000266593 date "1988-12-01" @default.
- W2000266593 modified "2023-09-26" @default.
- W2000266593 title "Protein-DNA interactions at the simian virus 40 origin of replication" @default.
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- W2000266593 doi "https://doi.org/10.1016/0167-4781(88)90111-x" @default.
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