FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000268209> ?p ?o ?g. }

• W2000268209 endingPage "108" @default.
• W2000268209 startingPage "103" @default.
• W2000268209 abstract "Somatic mutations of the epidermal growth factor receptor (EGFR) gene were found in about 25-40% of Japanese lung cancer patients. These mutations are associated with clinical and radiographic responses to EGFR tyrosine kinase inhibitors. Most common mutation are arginine for leucine substitution at amino acid 858 (L858R) and exon 19 deletions, especially deletion type 1 mutation. We investigated these EGFR mutation statuses in 575 surgically treated non-small cell lung cancer (NSCLC) cases. Three-hundred and sixty-two adenocarcinoma cases were included. The presence or absence of EGFR mutations of kinase domains was analyzed by genotyping analysis (TaqMan assay; n=386, and LightCycler assay; n=98) and sequences (n=91). EGFR mutations (CTG; CGG; L858R) were found from 63 of 575 lung cancer patients. We also detected the deletion 1a type mutations (2235-2249 del GGAATTAAGAGAAGC) from 39 patients and deletion 1b type mutations (2236-2250 del GAATTAAGAGAAGCA) from 15 patients in exon 19. These mutation statuses were significantly correlated with gender, smoking status (never smoker versus smoker), and pathological subtypes (adenocarcinoma versus non-adenocarcinoma). L858R mutation (p<0.0001), but not deletion 1 type mutation (p=0.0665), was correlated with differentiation status (well versus moderately or poorly) of lung cancers. L858R mutation ratio was significantly higher in non-smoker (p=0.0496) and adenocaicinoma (p=0.0136) when compared to deletion 1 type mutations. The EGFR mutation status, especially L858R mutation might be correlated with the clinico-pathological features related to good response to gefitinib, such as gender, smoking history, and pathological subtypes of Japanese lung cancers." @default.
• W2000268209 created "2016-06-24" @default.
• W2000268209 creator A5003703815 @default.
• W2000268209 creator A5006169496 @default.
• W2000268209 creator A5006601746 @default.
• W2000268209 creator A5025639736 @default.
• W2000268209 creator A5027162575 @default.
• W2000268209 creator A5031327561 @default.
• W2000268209 creator A5038239367 @default.
• W2000268209 creator A5044361715 @default.
• W2000268209 creator A5055251317 @default.
• W2000268209 creator A5057053465 @default.
• W2000268209 creator A5059047023 @default.
• W2000268209 creator A5061491770 @default.
• W2000268209 creator A5083971728 @default.
• W2000268209 creator A5084771205 @default.
• W2000268209 date "2006-10-01" @default.
• W2000268209 modified "2023-09-23" @default.
• W2000268209 title "L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer" @default.
• W2000268209 cites W1931438814 @default.
• W2000268209 cites W1997575097 @default.
• W2000268209 cites W2014187999 @default.
• W2000268209 cites W2016710415 @default.
• W2000268209 cites W2043696829 @default.
• W2000268209 cites W2051120695 @default.
• W2000268209 cites W2060084543 @default.
• W2000268209 cites W2111710483 @default.
• W2000268209 cites W2114642822 @default.
• W2000268209 cites W2117036891 @default.
• W2000268209 cites W2120718661 @default.
• W2000268209 cites W2125195105 @default.
• W2000268209 cites W2139236349 @default.
• W2000268209 cites W2143859186 @default.
• W2000268209 cites W2145640226 @default.
• W2000268209 cites W2146404049 @default.
• W2000268209 cites W2148174696 @default.
• W2000268209 cites W2153477391 @default.
• W2000268209 cites W2161821474 @default.
• W2000268209 cites W2168554121 @default.
• W2000268209 cites W4236601149 @default.
• W2000268209 doi "https://doi.org/10.1016/j.lungcan.2006.06.003" @default.
• W2000268209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16890322" @default.
• W2000268209 hasPublicationYear "2006" @default.
• W2000268209 type Work @default.
• W2000268209 sameAs 2000268209 @default.
• W2000268209 citedByCount "28" @default.
• W2000268209 countsByYear W20002682092013 @default.
• W2000268209 countsByYear W20002682092014 @default.
• W2000268209 countsByYear W20002682092015 @default.
• W2000268209 countsByYear W20002682092016 @default.
• W2000268209 countsByYear W20002682092017 @default.
• W2000268209 countsByYear W20002682092019 @default.
• W2000268209 countsByYear W20002682092020 @default.
• W2000268209 countsByYear W20002682092021 @default.
• W2000268209 countsByYear W20002682092022 @default.
• W2000268209 crossrefType "journal-article" @default.
• W2000268209 hasAuthorship W2000268209A5003703815 @default.
• W2000268209 hasAuthorship W2000268209A5006169496 @default.
• W2000268209 hasAuthorship W2000268209A5006601746 @default.
• W2000268209 hasAuthorship W2000268209A5025639736 @default.
• W2000268209 hasAuthorship W2000268209A5027162575 @default.
• W2000268209 hasAuthorship W2000268209A5031327561 @default.
• W2000268209 hasAuthorship W2000268209A5038239367 @default.
• W2000268209 hasAuthorship W2000268209A5044361715 @default.
• W2000268209 hasAuthorship W2000268209A5055251317 @default.
• W2000268209 hasAuthorship W2000268209A5057053465 @default.
• W2000268209 hasAuthorship W2000268209A5059047023 @default.
• W2000268209 hasAuthorship W2000268209A5061491770 @default.
• W2000268209 hasAuthorship W2000268209A5083971728 @default.
• W2000268209 hasAuthorship W2000268209A5084771205 @default.
• W2000268209 hasConcept C104317684 @default.
• W2000268209 hasConcept C121608353 @default.
• W2000268209 hasConcept C126322002 @default.
• W2000268209 hasConcept C142724271 @default.
• W2000268209 hasConcept C143998085 @default.
• W2000268209 hasConcept C176944494 @default.
• W2000268209 hasConcept C2776256026 @default.
• W2000268209 hasConcept C2777930144 @default.
• W2000268209 hasConcept C2779438470 @default.
• W2000268209 hasConcept C2780580887 @default.
• W2000268209 hasConcept C2781182431 @default.
• W2000268209 hasConcept C36823959 @default.
• W2000268209 hasConcept C501734568 @default.
• W2000268209 hasConcept C502942594 @default.
• W2000268209 hasConcept C54355233 @default.
• W2000268209 hasConcept C71924100 @default.
• W2000268209 hasConcept C86803240 @default.
• W2000268209 hasConceptScore W2000268209C104317684 @default.
• W2000268209 hasConceptScore W2000268209C121608353 @default.
• W2000268209 hasConceptScore W2000268209C126322002 @default.
• W2000268209 hasConceptScore W2000268209C142724271 @default.
• W2000268209 hasConceptScore W2000268209C143998085 @default.
• W2000268209 hasConceptScore W2000268209C176944494 @default.
• W2000268209 hasConceptScore W2000268209C2776256026 @default.
• W2000268209 hasConceptScore W2000268209C2777930144 @default.
• W2000268209 hasConceptScore W2000268209C2779438470 @default.
• W2000268209 hasConceptScore W2000268209C2780580887 @default.
• W2000268209 hasConceptScore W2000268209C2781182431 @default.

• next