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• W2000268368 abstract "A newly synthesized amino salicylato salt and its Cu(II) complex have effective inhibitory activity on hCAI and II. The Cu(II) complex crystallizes in the triclinic P 1 ¯ space group with a distorted square planar configuration. ► A novel amino salicylato salt and its Cu(II) complex have been synthesized. ► They have been characterized by elemental, spectral and thermal analyses. ► The single crystal X-ray diffraction technique have been applied to complex compound. ► These novel compounds have effective inhibitory activity on hCA I and II. ► They might be considered as prospective medicines for glaucoma. A novel amino salicylato salt, 2-amino-6-methylpyridinium 2-hydroxy-5-sulfonatobenzoate ( 1 ), and its Cu(II) complex, 2-ammonio-6-methylpyridinium bis(μ 6 -5-sulfonatosalicylatoaquacopper(II)) ( 2 ), have been synthesized from free ligands, namely 5-sulfosalicylic acid (H 3 ssa) and 2-amino-6-methylpyridine (amp). Compounds 1 and 2 have been characterized by elemental, spectral ( 1 H NMR, IR and UV–Vis) and thermal analyses. Additionally, magnetic measurements and the single crystal X-ray diffraction technique have been applied to compound 2 . Compound 2 crystallizes in the triclinic P 1 ¯ space group. In the symmetric unit, the Cu(II) ion exhibits a distorted square planar configuration, coordinated by two carboxylate oxygen atoms (O2 and O2 i ), one phenolic oxygen atom (O1) of the ssa 3− anion and a water molecule (O1w). The free ligands H 3 ssa and amp, and the products 1 and 2 , and acetazolamide (AAZ) as a control compound have been also evaluated for their in vitro inhibitor effects on human carbonic anhydrase isoenzymes (hCA I and hCA II), purified from the erythrocyte cell by affinity chromatography for their hydratase and esterase activities. In relation to esterase activities, the inhibition equilibrium constants ( K i) have also been determined. A comparison of the inhibition studies of the newly synthesized compounds 1 and 2 with the parent compounds H 3 ssa and amp, and to AAZ, indicates that 1 and 2 have an effective inhibitory activity on hCA I and II, and can be used as potential inhibitors." @default.
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• W2000268368 date "2011-02-01" @default.
• W2000268368 modified "2023-10-16" @default.
• W2000268368 title "Synthesis and characterization of a novel amino salicylato salt and its Cu(II) complex and their inhibition studies on carbonic anhydrase isoenzymes" @default.
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• W2000268368 doi "https://doi.org/10.1016/j.poly.2010.11.024" @default.
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