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- W2000269489 abstract "Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo studies then revealed the clinically relevant relationship between the channel expression and the pathogenesis of autoimmune diseases. In renal diseases, in which chronic inflammation or the overstimulation of cellular immunity is responsible for the pathogenesis, the overexpression of Kv1.3-channels in lymphocytes promotes their cellular proliferation and thus contributes to the progression of tubulointerstitial fibrosis. We recently demonstrated that benidipine, a potent dihydropyridine calcium channel blocker, which also strongly and persistently inhibits the lymphocyte Kv1.3-channel currents, suppressed the proliferation of kidney lymphocytes and actually ameliorated the progression of renal fibrosis. Based on the recent in vitro evidence that revealed the pharmacological properties of the channels, the most recent studies have revealed novel therapeutic implications of targeting the lymphocyte Kv1.3-channels for the treatment of renal diseases." @default.
- W2000269489 created "2016-06-24" @default.
- W2000269489 creator A5033550218 @default.
- W2000269489 date "2015-01-01" @default.
- W2000269489 modified "2023-09-23" @default.
- W2000269489 title "Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels" @default.
- W2000269489 cites W1492213776 @default.
- W2000269489 cites W1554754404 @default.
- W2000269489 cites W1598443371 @default.
- W2000269489 cites W1913534305 @default.
- W2000269489 cites W193198719 @default.
- W2000269489 cites W1936888634 @default.
- W2000269489 cites W1964407756 @default.
- W2000269489 cites W1965548299 @default.
- W2000269489 cites W1967152398 @default.
- W2000269489 cites W1969313581 @default.
- W2000269489 cites W1973670013 @default.
- W2000269489 cites W1975744071 @default.
- W2000269489 cites W1976194286 @default.
- W2000269489 cites W1976581530 @default.
- W2000269489 cites W1978611680 @default.
- W2000269489 cites W1979275881 @default.
- W2000269489 cites W1979823143 @default.
- W2000269489 cites W1979915354 @default.
- W2000269489 cites W1984298324 @default.
- W2000269489 cites W1984445978 @default.
- W2000269489 cites W1985610202 @default.
- W2000269489 cites W1987544121 @default.
- W2000269489 cites W1990905192 @default.
- W2000269489 cites W1997694477 @default.
- W2000269489 cites W1998104311 @default.
- W2000269489 cites W1999073594 @default.
- W2000269489 cites W1999919775 @default.
- W2000269489 cites W2002026389 @default.
- W2000269489 cites W2002346836 @default.
- W2000269489 cites W2003563340 @default.
- W2000269489 cites W2004604870 @default.
- W2000269489 cites W2004762745 @default.
- W2000269489 cites W2004947583 @default.
- W2000269489 cites W2007163913 @default.
- W2000269489 cites W2012254785 @default.
- W2000269489 cites W2014156502 @default.
- W2000269489 cites W2014163463 @default.
- W2000269489 cites W2016075027 @default.
- W2000269489 cites W2022968000 @default.
- W2000269489 cites W2023327369 @default.
- W2000269489 cites W2025642215 @default.
- W2000269489 cites W2025832002 @default.
- W2000269489 cites W2030790147 @default.
- W2000269489 cites W2034323825 @default.
- W2000269489 cites W2036704251 @default.
- W2000269489 cites W2037458332 @default.
- W2000269489 cites W2044549349 @default.
- W2000269489 cites W2044885944 @default.
- W2000269489 cites W2051785395 @default.
- W2000269489 cites W2051969301 @default.
- W2000269489 cites W2052246066 @default.
- W2000269489 cites W2059739500 @default.
- W2000269489 cites W2060201104 @default.
- W2000269489 cites W2067861417 @default.
- W2000269489 cites W2073970529 @default.
- W2000269489 cites W2074558075 @default.
- W2000269489 cites W2077156874 @default.
- W2000269489 cites W2080408828 @default.
- W2000269489 cites W2085146138 @default.
- W2000269489 cites W2085294587 @default.
- W2000269489 cites W2087151269 @default.
- W2000269489 cites W2089574338 @default.
- W2000269489 cites W2089595487 @default.
- W2000269489 cites W2091409101 @default.
- W2000269489 cites W2100516421 @default.
- W2000269489 cites W2104955621 @default.
- W2000269489 cites W2118593499 @default.
- W2000269489 cites W2123298850 @default.
- W2000269489 cites W2135762285 @default.
- W2000269489 cites W2136088665 @default.
- W2000269489 cites W2136526395 @default.
- W2000269489 cites W2140831927 @default.
- W2000269489 cites W2141578443 @default.
- W2000269489 cites W2151698714 @default.
- W2000269489 cites W2161742412 @default.
- W2000269489 cites W2170203080 @default.
- W2000269489 cites W2171028311 @default.
- W2000269489 cites W2171561606 @default.
- W2000269489 cites W2314738243 @default.
- W2000269489 cites W2318739344 @default.
- W2000269489 cites W2338256207 @default.
- W2000269489 cites W2344923489 @default.
- W2000269489 cites W2408298421 @default.
- W2000269489 cites W2409927683 @default.
- W2000269489 cites W2413523258 @default.
- W2000269489 cites W2464818914 @default.
- W2000269489 cites W3156148333 @default.
- W2000269489 cites W4302048212 @default.
- W2000269489 cites W994176246 @default.
- W2000269489 cites W2063084669 @default.
- W2000269489 doi "https://doi.org/10.1155/2015/436572" @default.
- W2000269489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4381730" @default.