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• W2000269678 abstract "Small RNAs are important regulators of gene expression. In maize, adaxial/abaxial (dorsoventral) leaf polarity is established by an abaxial gradient of microRNA166 (miR166), which spatially restricts the expression domain of class III homeodomain leucine zipper (HD-ZIPIII) transcription factors that specify adaxial/upper fate. Here, we show that leafbladeless1 encodes a key component in the trans-acting small interfering RNA (ta-siRNA) biogenesis pathway that acts on the adaxial side of developing leaves and demarcates the domains of hd-zipIII and miR166 accumulation. Our findings indicate that tasiR-ARF, a ta-siRNA, and miR166 establish opposing domains along the adaxial-abaxial axis, thus revealing a novel mechanism of pattern formation." @default.
• W2000269678 created "2016-06-24" @default.
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• W2000269678 date "2007-04-01" @default.
• W2000269678 modified "2023-10-18" @default.
• W2000269678 title "Two small regulatory RNAs establish opposing fates of a developmental axis" @default.
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• W2000269678 doi "https://doi.org/10.1101/gad.1528607" @default.
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