Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000270070> ?p ?o ?g. }
- W2000270070 endingPage "164" @default.
- W2000270070 startingPage "158" @default.
- W2000270070 abstract "Background: Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin dialysis in ALF with use of the Molecular Adsorbents Recirculating System without hemofiltration/dialysis (modified, M-MARS). Methods: Pigs were randomized into three groups: sham, ALF, and ALF + M-MARS. ALF was induced by hepatic devascularization (time = 0). M-MARS began at time = 2 and ended with the experiment at time = 6. ICP, arterial ammonia, brain water, cerebral blood flow (CBF), and plasma inflammatory markers were measured. Results: ICP and arterial ammonia increased significantly over 6 hrs in the ALF group, in comparison with the sham group. M-MARS attenuated (did not normalize) the increased ICP in the ALF group, whereas arterial ammonia was unaltered by M-MARS. Brain water in the frontal cortex (grey matter) and in the subcortical white matter at 6 hrs was significantly higher in the ALF group than in the sham group. M-MARS prevented a rise in water content, but only in white matter. CBF and inflammatory mediators remained unchanged in all groups. Conclusion: The initial development of cerebral edema and increased ICP occurs independently of CBF changes in this noninflammatory model of ALF. Factor(s) other than or in addition to hyperammonemia are important, however, and may be more amenable to alteration by albumin dialysis." @default.
- W2000270070 created "2016-06-24" @default.
- W2000270070 creator A5018816946 @default.
- W2000270070 creator A5027077891 @default.
- W2000270070 creator A5031757444 @default.
- W2000270070 creator A5033168111 @default.
- W2000270070 creator A5034857609 @default.
- W2000270070 creator A5046013731 @default.
- W2000270070 creator A5047324691 @default.
- W2000270070 creator A5049901772 @default.
- W2000270070 creator A5056338620 @default.
- W2000270070 creator A5064109879 @default.
- W2000270070 creator A5064314240 @default.
- W2000270070 creator A5072533237 @default.
- W2000270070 creator A5073459667 @default.
- W2000270070 creator A5083061422 @default.
- W2000270070 date "2006-01-01" @default.
- W2000270070 modified "2023-10-15" @default.
- W2000270070 title "Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: A randomized study*" @default.
- W2000270070 cites W1594663117 @default.
- W2000270070 cites W1608215573 @default.
- W2000270070 cites W1740096527 @default.
- W2000270070 cites W1969248415 @default.
- W2000270070 cites W1971234316 @default.
- W2000270070 cites W19827147 @default.
- W2000270070 cites W1983038501 @default.
- W2000270070 cites W1986913475 @default.
- W2000270070 cites W1987977677 @default.
- W2000270070 cites W2001087077 @default.
- W2000270070 cites W2008823889 @default.
- W2000270070 cites W2011674357 @default.
- W2000270070 cites W2015669226 @default.
- W2000270070 cites W2019548033 @default.
- W2000270070 cites W2021031224 @default.
- W2000270070 cites W2021710187 @default.
- W2000270070 cites W2031880480 @default.
- W2000270070 cites W2033568251 @default.
- W2000270070 cites W2037545737 @default.
- W2000270070 cites W2042484524 @default.
- W2000270070 cites W2042823827 @default.
- W2000270070 cites W2045403836 @default.
- W2000270070 cites W2046594543 @default.
- W2000270070 cites W2047392911 @default.
- W2000270070 cites W2050005201 @default.
- W2000270070 cites W2050083695 @default.
- W2000270070 cites W2050620959 @default.
- W2000270070 cites W2052238503 @default.
- W2000270070 cites W2052720481 @default.
- W2000270070 cites W2053277482 @default.
- W2000270070 cites W2054363735 @default.
- W2000270070 cites W2062170934 @default.
- W2000270070 cites W2066134367 @default.
- W2000270070 cites W2073460438 @default.
- W2000270070 cites W2083919057 @default.
- W2000270070 cites W2085246488 @default.
- W2000270070 cites W2086873275 @default.
- W2000270070 cites W2086957693 @default.
- W2000270070 cites W2088954626 @default.
- W2000270070 cites W2110164053 @default.
- W2000270070 cites W2112610029 @default.
- W2000270070 cites W2116188145 @default.
- W2000270070 cites W2123782394 @default.
- W2000270070 cites W2124287845 @default.
- W2000270070 cites W2131924534 @default.
- W2000270070 cites W2139131748 @default.
- W2000270070 cites W2151479000 @default.
- W2000270070 cites W2156324325 @default.
- W2000270070 cites W2160032995 @default.
- W2000270070 cites W2160749102 @default.
- W2000270070 cites W2330075190 @default.
- W2000270070 cites W2409131529 @default.
- W2000270070 cites W2417734270 @default.
- W2000270070 cites W98248761 @default.
- W2000270070 doi "https://doi.org/10.1097/01.ccm.0000196203.39832.3c" @default.
- W2000270070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16374170" @default.
- W2000270070 hasPublicationYear "2006" @default.
- W2000270070 type Work @default.
- W2000270070 sameAs 2000270070 @default.
- W2000270070 citedByCount "82" @default.
- W2000270070 countsByYear W20002700702012 @default.
- W2000270070 countsByYear W20002700702013 @default.
- W2000270070 countsByYear W20002700702014 @default.
- W2000270070 countsByYear W20002700702015 @default.
- W2000270070 countsByYear W20002700702016 @default.
- W2000270070 countsByYear W20002700702017 @default.
- W2000270070 countsByYear W20002700702018 @default.
- W2000270070 countsByYear W20002700702019 @default.
- W2000270070 countsByYear W20002700702020 @default.
- W2000270070 countsByYear W20002700702021 @default.
- W2000270070 countsByYear W20002700702023 @default.
- W2000270070 crossrefType "journal-article" @default.
- W2000270070 hasAuthorship W2000270070A5018816946 @default.
- W2000270070 hasAuthorship W2000270070A5027077891 @default.
- W2000270070 hasAuthorship W2000270070A5031757444 @default.
- W2000270070 hasAuthorship W2000270070A5033168111 @default.
- W2000270070 hasAuthorship W2000270070A5034857609 @default.
- W2000270070 hasAuthorship W2000270070A5046013731 @default.
- W2000270070 hasAuthorship W2000270070A5047324691 @default.