FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000270287> ?p ?o ?g. }

• W2000270287 endingPage "65" @default.
• W2000270287 startingPage "55" @default.
• W2000270287 abstract "Molecular dynamics simulations were employed to investigate the modulation of protein behaviors on the electrically responsive zwitterionic phosphorylcholine self-assembled monolayers (PC-SAMs). Results show that PC-SAMs could sensitively respond to the applied electric fields and exhibit three states with different charge distributions, namely both the negatively charged phosphate groups and the positively charged choline groups are exposed to the solution in the absence of electric fields (state 1), phosphate groups exposed in the presence of positive electric fields (state 2), and choline groups exposed in the presence of negative electric fields (state 3). Under state 1, the adsorption of Cyt c on the PC-SAM is reversible and the orientations of Cyt c are randomly distributed. Under state 2, the adsorption of Cyt c is enhanced due to the electrostatic attractions between the exposed phosphate groups and the positively charged protein; when adsorbed on the PC-SAMs, Cyt c tends to adopt the orientation with the heme plane perpendicular to the surface plane, and the percentage of this orientation increases as the field strength rises up. Under state 3, the adsorption of Cyt c is retarded because of the electrostatic repulsions between the exposed choline groups and the protein; however, if the gaps between PC chains are large enough, Cyt c could insert into the PC-SAM and access the phosphate groups after overcoming a slight energy barrier. Under three states, the basic backbone structures of Cyt c are well kept within the simulation time since the conformation of Cyt c is mainly affected by the surface-generated electric fields, whose strengths are modulated by the external electric fields and are not strong enough to deform protein. The results indicate the possibility of regulating protein behaviors, including promoting or retarding protein adsorption and regulating protein orientations, on responsive surfaces by applying electric fields on the surfaces without worrying protein deformation, which may be helpful in the applications of protein separation and controlled drug delivery." @default.
• W2000270287 created "2016-06-24" @default.
• W2000270287 creator A5003447105 @default.
• W2000270287 creator A5023595240 @default.
• W2000270287 creator A5059460662 @default.
• W2000270287 creator A5073242941 @default.
• W2000270287 creator A5083967189 @default.
• W2000270287 date "2015-01-01" @default.
• W2000270287 modified "2023-10-17" @default.
• W2000270287 title "Modulating protein behaviors on responsive surface by external electric fields: A molecular dynamics study" @default.
• W2000270287 cites W1966751543 @default.
• W2000270287 cites W1973285180 @default.
• W2000270287 cites W1975407877 @default.
• W2000270287 cites W1976719935 @default.
• W2000270287 cites W1978693732 @default.
• W2000270287 cites W1981904613 @default.
• W2000270287 cites W1982044972 @default.
• W2000270287 cites W1985029558 @default.
• W2000270287 cites W1995887706 @default.
• W2000270287 cites W2008007634 @default.
• W2000270287 cites W2010248529 @default.
• W2000270287 cites W2010372173 @default.
• W2000270287 cites W2012889959 @default.
• W2000270287 cites W2014020734 @default.
• W2000270287 cites W2016957303 @default.
• W2000270287 cites W2018700232 @default.
• W2000270287 cites W2019366993 @default.
• W2000270287 cites W2027408247 @default.
• W2000270287 cites W2027593766 @default.
• W2000270287 cites W2033989457 @default.
• W2000270287 cites W2034816658 @default.
• W2000270287 cites W2035266068 @default.
• W2000270287 cites W2039125370 @default.
• W2000270287 cites W2046427711 @default.
• W2000270287 cites W2046800491 @default.
• W2000270287 cites W2051196721 @default.
• W2000270287 cites W2053110759 @default.
• W2000270287 cites W2056056909 @default.
• W2000270287 cites W2058675715 @default.
• W2000270287 cites W2060170827 @default.
• W2000270287 cites W2061849375 @default.
• W2000270287 cites W2067295330 @default.
• W2000270287 cites W2068473628 @default.
• W2000270287 cites W2071172293 @default.
• W2000270287 cites W2075898913 @default.
• W2000270287 cites W2084976938 @default.
• W2000270287 cites W2086218859 @default.
• W2000270287 cites W2088046542 @default.
• W2000270287 cites W2092620004 @default.
• W2000270287 cites W2097773191 @default.
• W2000270287 cites W2108847852 @default.
• W2000270287 cites W2113495730 @default.
• W2000270287 cites W2120730989 @default.
• W2000270287 cites W2121276702 @default.
• W2000270287 cites W2122184599 @default.
• W2000270287 cites W2135629193 @default.
• W2000270287 cites W2136125528 @default.
• W2000270287 cites W2136769624 @default.
• W2000270287 cites W2162166182 @default.
• W2000270287 cites W2165443337 @default.
• W2000270287 cites W2165735280 @default.
• W2000270287 cites W2312225661 @default.
• W2000270287 cites W2312295720 @default.
• W2000270287 cites W2317691036 @default.
• W2000270287 cites W2318126316 @default.
• W2000270287 cites W2325717548 @default.
• W2000270287 cites W2333958487 @default.
• W2000270287 doi "https://doi.org/10.1016/j.apsusc.2014.11.078" @default.
• W2000270287 hasPublicationYear "2015" @default.
• W2000270287 type Work @default.
• W2000270287 sameAs 2000270287 @default.
• W2000270287 citedByCount "20" @default.
• W2000270287 countsByYear W20002702872015 @default.
• W2000270287 countsByYear W20002702872016 @default.
• W2000270287 countsByYear W20002702872017 @default.
• W2000270287 countsByYear W20002702872018 @default.
• W2000270287 countsByYear W20002702872019 @default.
• W2000270287 countsByYear W20002702872020 @default.
• W2000270287 countsByYear W20002702872021 @default.
• W2000270287 countsByYear W20002702872022 @default.
• W2000270287 countsByYear W20002702872023 @default.
• W2000270287 crossrefType "journal-article" @default.
• W2000270287 hasAuthorship W2000270287A5003447105 @default.
• W2000270287 hasAuthorship W2000270287A5023595240 @default.
• W2000270287 hasAuthorship W2000270287A5059460662 @default.
• W2000270287 hasAuthorship W2000270287A5073242941 @default.
• W2000270287 hasAuthorship W2000270287A5083967189 @default.
• W2000270287 hasConcept C117626034 @default.
• W2000270287 hasConcept C121332964 @default.
• W2000270287 hasConcept C147597530 @default.
• W2000270287 hasConcept C147789679 @default.
• W2000270287 hasConcept C150394285 @default.
• W2000270287 hasConcept C159467904 @default.
• W2000270287 hasConcept C178790620 @default.
• W2000270287 hasConcept C185592680 @default.
• W2000270287 hasConcept C55493867 @default.
• W2000270287 hasConcept C59593255 @default.
• W2000270287 hasConcept C60799052 @default.

• next