FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000271119> ?p ?o ?g. }

• W2000271119 endingPage "429" @default.
• W2000271119 startingPage "417" @default.
• W2000271119 abstract "MicroRNAs (miRNAs) are a class of small, noncoding RNAs that play crucial roles in almost all cellular processes. As key post-transcriptional regulators of gene expression, miRNAs mainly induce mRNA degradation or translational repression. Recently computational and experimental studies have identified an abundance of motifs involving miRNAs and transcriptional factors (TFs). Here, we study the functional characteristics of one such motif, a two-node miRNA-mediated double negative feedback loop (MDNFL) in which a TF suppresses an miRNA and the TF itself is negatively regulated by the miRNA. Several examples of this motif are described from the literature. We propose a general computational model for the MDNFL based on biochemical regulations and explore its dynamics by using bifurcation analysis. Our results show that the MDNFL can behave as a bistable switch. This functional feature is in agreement with experimental observations of the widespread appearance of miRNAs in fate decisions such as differentiation during development. Importantly, it is found that under the interplay of a TF and an miRNA, the MDNFL model can behave as switches for wide ranges of parameters even without cooperative binding of the TF. In addition, we also investigate how extrinsic noise affects dynamic behavior of the MDNFL. Interestingly, it is found that when the MDNFL is in the bistable region, by choosing the appropriate extrinsic noise source, the MDNFL system can switch from one steady state to the other and meanwhile the production of either miRNA or protein is amplified significantly. From an engineering perspective, this noise-based switch and amplifier for gene expression is very easy to control. It is hoped that the results presented here would provide a new insight on how gene expression is regulated by miRNAs and further guidance for experiments." @default.
• W2000271119 created "2016-06-24" @default.
• W2000271119 creator A5043253743 @default.
• W2000271119 creator A5063866156 @default.
• W2000271119 creator A5079748539 @default.
• W2000271119 date "2013-01-05" @default.
• W2000271119 modified "2023-10-16" @default.
• W2000271119 title "Functional characteristics of a double negative feedback loop mediated by microRNAs" @default.
• W2000271119 cites W144423133 @default.
• W2000271119 cites W1648301895 @default.
• W2000271119 cites W1804959557 @default.
• W2000271119 cites W1963811831 @default.
• W2000271119 cites W1975437957 @default.
• W2000271119 cites W1975507969 @default.
• W2000271119 cites W1980389572 @default.
• W2000271119 cites W1988791304 @default.
• W2000271119 cites W1992696908 @default.
• W2000271119 cites W1994032485 @default.
• W2000271119 cites W1996441871 @default.
• W2000271119 cites W1999716743 @default.
• W2000271119 cites W2000418014 @default.
• W2000271119 cites W2004203502 @default.
• W2000271119 cites W2004995323 @default.
• W2000271119 cites W2008855387 @default.
• W2000271119 cites W2011504420 @default.
• W2000271119 cites W2014946489 @default.
• W2000271119 cites W2015858554 @default.
• W2000271119 cites W2017270642 @default.
• W2000271119 cites W2018450278 @default.
• W2000271119 cites W2019028138 @default.
• W2000271119 cites W2021014344 @default.
• W2000271119 cites W2029146318 @default.
• W2000271119 cites W2030166934 @default.
• W2000271119 cites W2032380268 @default.
• W2000271119 cites W2037992356 @default.
• W2000271119 cites W2039141906 @default.
• W2000271119 cites W2039245762 @default.
• W2000271119 cites W2039814743 @default.
• W2000271119 cites W2040851473 @default.
• W2000271119 cites W2043169862 @default.
• W2000271119 cites W2043946672 @default.
• W2000271119 cites W2045345510 @default.
• W2000271119 cites W2047365291 @default.
• W2000271119 cites W2049336663 @default.
• W2000271119 cites W2058553562 @default.
• W2000271119 cites W2058938112 @default.
• W2000271119 cites W2061425021 @default.
• W2000271119 cites W2064483836 @default.
• W2000271119 cites W2066235893 @default.
• W2000271119 cites W2077326330 @default.
• W2000271119 cites W2077336113 @default.
• W2000271119 cites W2078097311 @default.
• W2000271119 cites W2092019227 @default.
• W2000271119 cites W2095375866 @default.
• W2000271119 cites W2096511406 @default.
• W2000271119 cites W2098045561 @default.
• W2000271119 cites W2101744311 @default.
• W2000271119 cites W2102643936 @default.
• W2000271119 cites W2106362845 @default.
• W2000271119 cites W2107677744 @default.
• W2000271119 cites W2108493072 @default.
• W2000271119 cites W2110699703 @default.
• W2000271119 cites W2111268021 @default.
• W2000271119 cites W2111783800 @default.
• W2000271119 cites W2112666597 @default.
• W2000271119 cites W2114870653 @default.
• W2000271119 cites W2123880844 @default.
• W2000271119 cites W2125622282 @default.
• W2000271119 cites W2126188755 @default.
• W2000271119 cites W2126602684 @default.
• W2000271119 cites W2133968430 @default.
• W2000271119 cites W2134759932 @default.
• W2000271119 cites W2137727595 @default.
• W2000271119 cites W2142072523 @default.
• W2000271119 cites W2142310248 @default.
• W2000271119 cites W2145137020 @default.
• W2000271119 cites W2152310279 @default.
• W2000271119 cites W2154030625 @default.
• W2000271119 cites W2159579373 @default.
• W2000271119 cites W2159742844 @default.
• W2000271119 cites W2159767268 @default.
• W2000271119 cites W2160803964 @default.
• W2000271119 cites W2161693225 @default.
• W2000271119 cites W2170139221 @default.
• W2000271119 cites W2171488801 @default.
• W2000271119 cites W3104970623 @default.
• W2000271119 cites W4237011200 @default.
• W2000271119 doi "https://doi.org/10.1007/s11571-012-9236-7" @default.
• W2000271119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3773322" @default.
• W2000271119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24427216" @default.
• W2000271119 hasPublicationYear "2013" @default.
• W2000271119 type Work @default.
• W2000271119 sameAs 2000271119 @default.
• W2000271119 citedByCount "19" @default.
• W2000271119 countsByYear W20002711192014 @default.
• W2000271119 countsByYear W20002711192015 @default.
• W2000271119 countsByYear W20002711192016 @default.
• W2000271119 countsByYear W20002711192017 @default.

• next