FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000272648> ?p ?o ?g. }

• W2000272648 endingPage "289" @default.
• W2000272648 startingPage "283" @default.
• W2000272648 abstract "Objectives: The cytokine receptor activator of nuclear factor κ B‐ligand (RANKL) has been involved in both the physiological and pathological regulation of osteoclast life span and bone metabolism. Periapical granuloma is a periradicular lesion characterized by periapical bone destruction. The aims of this study were to associate the RANKL mRNA levels to periapical granulomas using the real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) technique and to determine the specific cell involved in RANKL synthesis. Methods: In eight periapical granuloma and eight periodontal ligament samples from periodontally healthy volunteers, RANKL mRNA was detected by real‐time RT‐PCR. Expression of RANKL on infiltrate leukocytes was further investigated by flow cytometry in six periapical granulomas. Results: Receptor activator of nuclear factor κ B‐ligand mRNA levels were higher in periapical granulomas than in healthy periodontal ligament as its RANKL mRNA cycle threshold (Ct) and ΔCt were significantly lower than that of controls (33.07 ± 1.24 vs 36.96 ± 1.69 and 11.58 ± 3.02 vs 15.60 ± 3.31, respectively). A 16.2‐fold (2.0–131.6) higher RANKL gene expression was detected in the granulomas compared with the control tissues. We determined by flow cytometry that lymphocytes were the predominant leukocyte cells (53.31%), and monocytes and dendritic cells were the main RANKL synthesizers in granuloma lesions. Conclusions: These data indicate that monocytes synthesized RANKL in periapical granulomas and suggest that RANKL is involved in bone loss associated with periapical lesions." @default.
• W2000272648 created "2016-06-24" @default.
• W2000272648 creator A5004492433 @default.
• W2000272648 creator A5005402084 @default.
• W2000272648 creator A5014119951 @default.
• W2000272648 creator A5024120372 @default.
• W2000272648 creator A5041806495 @default.
• W2000272648 creator A5063329957 @default.
• W2000272648 creator A5072662001 @default.
• W2000272648 creator A5086935056 @default.
• W2000272648 date "2006-02-28" @default.
• W2000272648 modified "2023-10-16" @default.
• W2000272648 title "RANKL in human periapical granuloma: possible involvement in periapical bone destruction" @default.
• W2000272648 cites W127005697 @default.
• W2000272648 cites W1572906866 @default.
• W2000272648 cites W1677043489 @default.
• W2000272648 cites W1910581214 @default.
• W2000272648 cites W1952915179 @default.
• W2000272648 cites W1976690809 @default.
• W2000272648 cites W1982381891 @default.
• W2000272648 cites W1984631633 @default.
• W2000272648 cites W1994767910 @default.
• W2000272648 cites W1996682859 @default.
• W2000272648 cites W2001702627 @default.
• W2000272648 cites W2011897165 @default.
• W2000272648 cites W2020066699 @default.
• W2000272648 cites W2032876833 @default.
• W2000272648 cites W2048299560 @default.
• W2000272648 cites W2053069753 @default.
• W2000272648 cites W2055166353 @default.
• W2000272648 cites W2066080623 @default.
• W2000272648 cites W2067993670 @default.
• W2000272648 cites W2070929506 @default.
• W2000272648 cites W2084490580 @default.
• W2000272648 cites W2105682215 @default.
• W2000272648 cites W2107277218 @default.
• W2000272648 cites W2119077780 @default.
• W2000272648 cites W2121778907 @default.
• W2000272648 cites W2124095779 @default.
• W2000272648 cites W2124418728 @default.
• W2000272648 cites W2128088040 @default.
• W2000272648 cites W2138986878 @default.
• W2000272648 cites W2142596182 @default.
• W2000272648 cites W2170384111 @default.
• W2000272648 doi "https://doi.org/10.1111/j.1601-0825.2005.01191.x" @default.
• W2000272648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16700737" @default.
• W2000272648 hasPublicationYear "2006" @default.
• W2000272648 type Work @default.
• W2000272648 sameAs 2000272648 @default.
• W2000272648 citedByCount "74" @default.
• W2000272648 countsByYear W20002726482012 @default.
• W2000272648 countsByYear W20002726482013 @default.
• W2000272648 countsByYear W20002726482014 @default.
• W2000272648 countsByYear W20002726482015 @default.
• W2000272648 countsByYear W20002726482016 @default.
• W2000272648 countsByYear W20002726482017 @default.
• W2000272648 countsByYear W20002726482019 @default.
• W2000272648 countsByYear W20002726482020 @default.
• W2000272648 countsByYear W20002726482022 @default.
• W2000272648 countsByYear W20002726482023 @default.
• W2000272648 crossrefType "journal-article" @default.
• W2000272648 hasAuthorship W2000272648A5004492433 @default.
• W2000272648 hasAuthorship W2000272648A5005402084 @default.
• W2000272648 hasAuthorship W2000272648A5014119951 @default.
• W2000272648 hasAuthorship W2000272648A5024120372 @default.
• W2000272648 hasAuthorship W2000272648A5041806495 @default.
• W2000272648 hasAuthorship W2000272648A5063329957 @default.
• W2000272648 hasAuthorship W2000272648A5072662001 @default.
• W2000272648 hasAuthorship W2000272648A5086935056 @default.
• W2000272648 hasBestOaLocation W20002726482 @default.
• W2000272648 hasConcept C126322002 @default.
• W2000272648 hasConcept C142724271 @default.
• W2000272648 hasConcept C170033053 @default.
• W2000272648 hasConcept C170493617 @default.
• W2000272648 hasConcept C199343813 @default.
• W2000272648 hasConcept C203014093 @default.
• W2000272648 hasConcept C2776033226 @default.
• W2000272648 hasConcept C2777109110 @default.
• W2000272648 hasConcept C2779428903 @default.
• W2000272648 hasConcept C2780140890 @default.
• W2000272648 hasConcept C2780385504 @default.
• W2000272648 hasConcept C2780426850 @default.
• W2000272648 hasConcept C41868710 @default.
• W2000272648 hasConcept C553184892 @default.
• W2000272648 hasConcept C71924100 @default.
• W2000272648 hasConcept C88045685 @default.
• W2000272648 hasConceptScore W2000272648C126322002 @default.
• W2000272648 hasConceptScore W2000272648C142724271 @default.
• W2000272648 hasConceptScore W2000272648C170033053 @default.
• W2000272648 hasConceptScore W2000272648C170493617 @default.
• W2000272648 hasConceptScore W2000272648C199343813 @default.
• W2000272648 hasConceptScore W2000272648C203014093 @default.
• W2000272648 hasConceptScore W2000272648C2776033226 @default.
• W2000272648 hasConceptScore W2000272648C2777109110 @default.
• W2000272648 hasConceptScore W2000272648C2779428903 @default.
• W2000272648 hasConceptScore W2000272648C2780140890 @default.
• W2000272648 hasConceptScore W2000272648C2780385504 @default.
• W2000272648 hasConceptScore W2000272648C2780426850 @default.

• next