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• W2000272671 abstract "Injection of endothelial progenitor cells (EPC) expanded ex vivo has been shown to increase neovascularization in preclinical models of ischemia and in adult patients, but the precise origin and identity of the cell population responsible for these clinical benefits are controversial. Given the potential usefulness of EPC as a cell therapy product, their thorough characterization is of major importance. This review describes the two cell populations currently called EPC and the means to find differential phenotypic markers. We have shown that BMP2/4 are specific markers of late EPC and play a key role in EPC commitment and outgrowth during neovascularization. Several authors have attempted to expand EPC ex vivo in order to obtain a homogeneous cell therapy product. One possible mean of expanding EPC ex vivo is to activate the thrombin receptor PAR-1 with the specific peptide SFLLRN. Indeed, PAR-1 activation increases angiogenic properties of EPC through activation of SDF-1, angiopoietin and IL-8 pathways. This review summarizes the characterization of EPC and different methods of ex vivo expansion." @default.
• W2000272671 created "2016-06-24" @default.
• W2000272671 creator A5015477632 @default.
• W2000272671 creator A5067874747 @default.
• W2000272671 date "2009-01-01" @default.
• W2000272671 modified "2023-09-30" @default.
• W2000272671 title "Caractérisation des progéniteurs endothéliaux et stratégies d'expansionin vitro" @default.
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• W2000272671 doi "https://doi.org/10.1051/jbio/2009024" @default.
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