FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000274136> ?p ?o ?g. }

• W2000274136 endingPage "163" @default.
• W2000274136 startingPage "163" @default.
• W2000274136 abstract "<ns4:p>Ectonucleotidases are membrane-bound or secreted proteins that hydrolyze extracellular nucleotides. Recently, we identified three ectonucleotidases that hydrolyze extracellular adenosine 5’-monophosphate (AMP) to adenosine in primary somatosensory neurons. Currently, it is unclear which ectonucleotidases hydrolyze ATP and ADP in these neurons. Ectonucleoside triphosphate diphosphohydrolases (ENTPDs) comprise a class of enzymes that dephosphorylate extracellular ATP and ADP. Here, we found that ENTPD3 (also known as NTPDase3 or CD39L3) was located in nociceptive and non-nociceptive neurons of the dorsal root ganglion (DRG), in the dorsal horn of the spinal cord, and in free nerve endings in the skin. To determine if ENTPD3 contributes directly to ATP and ADP hydrolysis in these tissues, we generated and characterized an <ns4:italic>Entpd3</ns4:italic> knockout mouse. This mouse lacks ENTPD3 protein in all tissues examined, including the DRG, spinal cord, skin, and bladder. However, DRG and spinal cord tissues from <ns4:italic>Entpd3<ns4:sup>-/-</ns4:sup></ns4:italic> mice showed no reduction in histochemical staining when ATP, ADP, AMP, or UTP were used as substrates. Additionally, using fast-scan cyclic voltammetry (FSCV), adenosine production was not impaired in the dorsal spinal cord of <ns4:italic>Entpd3<ns4:sup>-/-</ns4:sup></ns4:italic> mice when the substrate ADP was applied. Further, <ns4:italic>Entpd3<ns4:sup>-/- </ns4:sup></ns4:italic>mice did not differ in nociceptive behaviors when compared to wild-type mice, although <ns4:italic>Entpd3<ns4:sup>-/- </ns4:sup></ns4:italic>mice showed a modest reduction in β-alanine-mediated itch. Taken together, our data indicate that deletion of <ns4:italic>Entpd3</ns4:italic> does not impair ATP or ADP hydrolysis in primary somatosensory neurons or in dorsal spinal cord. Moreover, our data suggest there could be multiple ectonucleotidases that act redundantly to hydrolyze nucleotides in these regions of the nervous system.</ns4:p>" @default.
• W2000274136 created "2016-06-24" @default.
• W2000274136 creator A5000485305 @default.
• W2000274136 creator A5012941254 @default.
• W2000274136 creator A5047547845 @default.
• W2000274136 creator A5073163069 @default.
• W2000274136 creator A5077448799 @default.
• W2000274136 creator A5078210617 @default.
• W2000274136 creator A5080709947 @default.
• W2000274136 date "2014-09-19" @default.
• W2000274136 modified "2023-09-27" @default.
• W2000274136 title "Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord" @default.
• W2000274136 cites W134994456 @default.
• W2000274136 cites W1498618829 @default.
• W2000274136 cites W1965018866 @default.
• W2000274136 cites W1965903365 @default.
• W2000274136 cites W1967430693 @default.
• W2000274136 cites W1975332997 @default.
• W2000274136 cites W1975979472 @default.
• W2000274136 cites W1976696638 @default.
• W2000274136 cites W1981669433 @default.
• W2000274136 cites W1985703062 @default.
• W2000274136 cites W1986885145 @default.
• W2000274136 cites W1989837824 @default.
• W2000274136 cites W1996180725 @default.
• W2000274136 cites W1997053106 @default.
• W2000274136 cites W2002620715 @default.
• W2000274136 cites W2003830841 @default.
• W2000274136 cites W2004301965 @default.
• W2000274136 cites W2005542488 @default.
• W2000274136 cites W2007354524 @default.
• W2000274136 cites W2007721271 @default.
• W2000274136 cites W2013195053 @default.
• W2000274136 cites W2014760856 @default.
• W2000274136 cites W2016300311 @default.
• W2000274136 cites W2021640479 @default.
• W2000274136 cites W2029211558 @default.
• W2000274136 cites W2032154466 @default.
• W2000274136 cites W2034009099 @default.
• W2000274136 cites W2039503743 @default.
• W2000274136 cites W2045606714 @default.
• W2000274136 cites W2050725524 @default.
• W2000274136 cites W2056123178 @default.
• W2000274136 cites W2056407069 @default.
• W2000274136 cites W2074274384 @default.
• W2000274136 cites W2083457444 @default.
• W2000274136 cites W2083751011 @default.
• W2000274136 cites W2088291447 @default.
• W2000274136 cites W2095988220 @default.
• W2000274136 cites W2096563065 @default.
• W2000274136 cites W2105791073 @default.
• W2000274136 cites W2107270966 @default.
• W2000274136 cites W2111106575 @default.
• W2000274136 cites W2118114528 @default.
• W2000274136 cites W2119872155 @default.
• W2000274136 cites W2126082233 @default.
• W2000274136 cites W2126229620 @default.
• W2000274136 cites W2127001240 @default.
• W2000274136 cites W2130420429 @default.
• W2000274136 cites W2131664490 @default.
• W2000274136 cites W2153132454 @default.
• W2000274136 cites W2163985126 @default.
• W2000274136 cites W2169667134 @default.
• W2000274136 cites W2170477092 @default.
• W2000274136 doi "https://doi.org/10.12688/f1000research.4563.2" @default.
• W2000274136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4329602" @default.
• W2000274136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25729567" @default.
• W2000274136 hasPublicationYear "2014" @default.
• W2000274136 type Work @default.
• W2000274136 sameAs 2000274136 @default.
• W2000274136 citedByCount "8" @default.
• W2000274136 countsByYear W20002741362016 @default.
• W2000274136 countsByYear W20002741362018 @default.
• W2000274136 countsByYear W20002741362020 @default.
• W2000274136 countsByYear W20002741362021 @default.
• W2000274136 countsByYear W20002741362022 @default.
• W2000274136 crossrefType "journal-article" @default.
• W2000274136 hasAuthorship W2000274136A5000485305 @default.
• W2000274136 hasAuthorship W2000274136A5012941254 @default.
• W2000274136 hasAuthorship W2000274136A5047547845 @default.
• W2000274136 hasAuthorship W2000274136A5073163069 @default.
• W2000274136 hasAuthorship W2000274136A5077448799 @default.
• W2000274136 hasAuthorship W2000274136A5078210617 @default.
• W2000274136 hasAuthorship W2000274136A5080709947 @default.
• W2000274136 hasBestOaLocation W20002741361 @default.
• W2000274136 hasConcept C105702510 @default.
• W2000274136 hasConcept C15490471 @default.
• W2000274136 hasConcept C169760540 @default.
• W2000274136 hasConcept C170493617 @default.
• W2000274136 hasConcept C2780775167 @default.
• W2000274136 hasConcept C55493867 @default.
• W2000274136 hasConcept C86803240 @default.
• W2000274136 hasConceptScore W2000274136C105702510 @default.
• W2000274136 hasConceptScore W2000274136C15490471 @default.
• W2000274136 hasConceptScore W2000274136C169760540 @default.
• W2000274136 hasConceptScore W2000274136C170493617 @default.
• W2000274136 hasConceptScore W2000274136C2780775167 @default.
• W2000274136 hasConceptScore W2000274136C55493867 @default.

• next