Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000276002> ?p ?o ?g. }
- W2000276002 endingPage "1949" @default.
- W2000276002 startingPage "1937" @default.
- W2000276002 abstract "Physical activity preserves cognition in the aging brain, but the mechanisms remain obscure. In order to identify candidate genes and pathways responsible for the preservation of cognitive function by exercise, we trained mice that had been exposed to lifelong running or sedentary lifestyle for 16 months in the hippocampus-dependent water maze. After water maze training, we analyzed the expression of 24,000 genes in the hippocampus using Illumina bead microarray. Runners show greater activation of genes associated with synaptic plasticity and mitochondrial function, and also exhibit significant downregulation of genes associated with oxidative stress and lipid metabolism. Running also modified the effects of learning on the expression of genes involved in cell excitability, energy metabolism, and insulin, MAP kinase and Wnt signaling. These results suggest that the enhancement of cognitive function by lifelong exercise is associated with an altered transcriptional profile following learning." @default.
- W2000276002 created "2016-06-24" @default.
- W2000276002 creator A5017444330 @default.
- W2000276002 creator A5017462929 @default.
- W2000276002 creator A5033862949 @default.
- W2000276002 creator A5039481077 @default.
- W2000276002 creator A5052081713 @default.
- W2000276002 creator A5061101747 @default.
- W2000276002 creator A5082792278 @default.
- W2000276002 creator A5083040475 @default.
- W2000276002 date "2010-11-01" @default.
- W2000276002 modified "2023-10-18" @default.
- W2000276002 title "Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice" @default.
- W2000276002 cites W159568746 @default.
- W2000276002 cites W1959902108 @default.
- W2000276002 cites W1966538379 @default.
- W2000276002 cites W1984551681 @default.
- W2000276002 cites W1986618663 @default.
- W2000276002 cites W2000265708 @default.
- W2000276002 cites W2021551531 @default.
- W2000276002 cites W2038440451 @default.
- W2000276002 cites W2040405257 @default.
- W2000276002 cites W2050066016 @default.
- W2000276002 cites W2057121506 @default.
- W2000276002 cites W2061733344 @default.
- W2000276002 cites W2064397103 @default.
- W2000276002 cites W2066151668 @default.
- W2000276002 cites W2066191550 @default.
- W2000276002 cites W2067570041 @default.
- W2000276002 cites W2072805693 @default.
- W2000276002 cites W2073855709 @default.
- W2000276002 cites W2077741216 @default.
- W2000276002 cites W2089204174 @default.
- W2000276002 cites W2096192426 @default.
- W2000276002 cites W2108529838 @default.
- W2000276002 cites W2113238381 @default.
- W2000276002 cites W2120447295 @default.
- W2000276002 cites W2122253235 @default.
- W2000276002 cites W2123541107 @default.
- W2000276002 cites W2131545168 @default.
- W2000276002 cites W2146310895 @default.
- W2000276002 cites W2147162709 @default.
- W2000276002 cites W2163724452 @default.
- W2000276002 cites W2169294911 @default.
- W2000276002 doi "https://doi.org/10.1016/j.neurobiolaging.2008.10.016" @default.
- W2000276002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2889222" @default.
- W2000276002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19070401" @default.
- W2000276002 hasPublicationYear "2010" @default.
- W2000276002 type Work @default.
- W2000276002 sameAs 2000276002 @default.
- W2000276002 citedByCount "131" @default.
- W2000276002 countsByYear W20002760022012 @default.
- W2000276002 countsByYear W20002760022013 @default.
- W2000276002 countsByYear W20002760022014 @default.
- W2000276002 countsByYear W20002760022015 @default.
- W2000276002 countsByYear W20002760022016 @default.
- W2000276002 countsByYear W20002760022017 @default.
- W2000276002 countsByYear W20002760022018 @default.
- W2000276002 countsByYear W20002760022019 @default.
- W2000276002 countsByYear W20002760022020 @default.
- W2000276002 countsByYear W20002760022021 @default.
- W2000276002 countsByYear W20002760022022 @default.
- W2000276002 countsByYear W20002760022023 @default.
- W2000276002 crossrefType "journal-article" @default.
- W2000276002 hasAuthorship W2000276002A5017444330 @default.
- W2000276002 hasAuthorship W2000276002A5017462929 @default.
- W2000276002 hasAuthorship W2000276002A5033862949 @default.
- W2000276002 hasAuthorship W2000276002A5039481077 @default.
- W2000276002 hasAuthorship W2000276002A5052081713 @default.
- W2000276002 hasAuthorship W2000276002A5061101747 @default.
- W2000276002 hasAuthorship W2000276002A5082792278 @default.
- W2000276002 hasAuthorship W2000276002A5083040475 @default.
- W2000276002 hasBestOaLocation W20002760022 @default.
- W2000276002 hasConcept C104317684 @default.
- W2000276002 hasConcept C12515866 @default.
- W2000276002 hasConcept C127561419 @default.
- W2000276002 hasConcept C134018914 @default.
- W2000276002 hasConcept C137620995 @default.
- W2000276002 hasConcept C148762608 @default.
- W2000276002 hasConcept C150194340 @default.
- W2000276002 hasConcept C169760540 @default.
- W2000276002 hasConcept C170493617 @default.
- W2000276002 hasConcept C186836561 @default.
- W2000276002 hasConcept C2781161787 @default.
- W2000276002 hasConcept C44752575 @default.
- W2000276002 hasConcept C4733338 @default.
- W2000276002 hasConcept C47611674 @default.
- W2000276002 hasConcept C54355233 @default.
- W2000276002 hasConcept C8415881 @default.
- W2000276002 hasConcept C86803240 @default.
- W2000276002 hasConcept C98229152 @default.
- W2000276002 hasConceptScore W2000276002C104317684 @default.
- W2000276002 hasConceptScore W2000276002C12515866 @default.
- W2000276002 hasConceptScore W2000276002C127561419 @default.
- W2000276002 hasConceptScore W2000276002C134018914 @default.
- W2000276002 hasConceptScore W2000276002C137620995 @default.
- W2000276002 hasConceptScore W2000276002C148762608 @default.
- W2000276002 hasConceptScore W2000276002C150194340 @default.