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- W2000276146 abstract "Fibroblast interferon at a dosage of28 × 106 U/wk failed to influence disease progression in a preterminal case of therapy-resistant light chain myeloma. In a second case, that had not previously been treated, a first course of fibroblast interferon (30 × 106 U/wk) associated with corticosteroids remained without effect. In this patient subsequent leukocyte interferon treatment was associated with a decrease in urinary light chain excretion and normalization of calcaemia, all other parameters remaining unaltered. A third patient with light chain disease was resistant to chemotherapyab origine. None of the disease parameters responded to either fibroblast or leukocyte interferon therapy (21 × 106 U/wk). During therapy a downward trend occurred in the relative number of lymphocytes characterizable as B and T cells. Mitogenic reactivity remained unchanged except for a downward trend, during fibroblast interferon therapy, in reactivity to PHA and Con A after6 days culturing. Spontaneous (background) mitogenesis upon culture showed an upward trend." @default.
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- W2000276146 date "1981-08-01" @default.
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- W2000276146 title "Interferon therapy in multiple myeloma: Failure of human fibroblast interferon administration to affect the course of light chain disease" @default.
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- W2000276146 doi "https://doi.org/10.1016/0014-2964(81)90308-x" @default.
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