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- W2000276977 abstract "Sir,It is usually assumed in general medical practice that when a sick person develops a depressed mood, this is an understandable consequence of factors such as restricted physical activity and pain. An alternative perspective has been argued, which suggests that classical ‘depressive’ symptoms are often caused by activation of the immune system (especially cytokines such as interleukins, interferons and tumour necrosis factor, etc) which produces a state of malaise.1,,2Malaise comprises fatigue, heaviness, dull pains, aching of limbs and trunk, lack of energy and altered sleep patterns. These depressive symptoms seem to be the human equivalent of ‘sickness behaviour’ which is a stereotypical response of mammals suffering from infectious or inflammatory diseases.3 In other words, malaise is a behavioural …" @default.
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- W2000276977 date "2001-12-01" @default.
- W2000276977 modified "2023-09-23" @default.
- W2000276977 title "Depressive symptoms in injury and illness" @default.
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- W2000276977 doi "https://doi.org/10.1093/qjmed/94.12.720" @default.
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