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• W2000277025 endingPage "796" @default.
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• W2000277025 abstract "Cytosolic-free Ca2 + plays a crucial role in blood platelet function and is essential for thrombosis and hemostasis. Therefore, cytosolic-free Ca2 + concentration is tightly regulated in this cell. TRPC6 is expressed in platelets, and an important role for this Ca2 + channel in Ca2 + homeostasis has been reported in other cell types. The aim of this work is to study the function of TRPC6 in platelet Ca2 + homeostasis. The absence of TRPC6 resulted in an 18.73% decreased basal [Ca2 +]c in resting platelets as compared to control cells. Further analysis confirmed a similar Ca2 + accumulation in wild-type and TRPC6-deficient mice; however, passive Ca2 + leak rates from agonist-sensitive intracellular stores were significantly decreased in TRPC6-deficient platelets. Biotinylation studies indicated the presence of an intracellular TRPC6 population, and subcellular fractionation indicated their presence on endoplasmic reticulum membranes. Moreover, the presence of intracellular calcium release in platelets stimulated with 1-oleoyl-2-acetyl-sn-glycerol further suggested a functional TRPC6 population located on the intracellular membranes surrounding calcium stores. However, coimmunoprecipitation assay confirmed the absence of STIM1–TRPC6 interactions in resting conditions. This findings together with the absence of extracellular Mn2 + entry in resting wild-type platelets indicate that the plasma membrane TRPC6 fraction does not play a significant role in the maintenance of basal [Ca2 +]c in mouse platelets. Our results suggest an active participation of the intracellular TRPC6 fraction as a regulator of basal [Ca2 +]c, controlling the passive Ca2 + leak rate from agonist-sensitive intracellular Ca2 + stores in resting platelets." @default.
• W2000277025 created "2016-06-24" @default.
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• W2000277025 date "2014-04-01" @default.
• W2000277025 modified "2023-09-27" @default.
• W2000277025 title "TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets" @default.
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• W2000277025 doi "https://doi.org/10.1016/j.bbamcr.2014.01.014" @default.
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