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- W2000277813 abstract "Recombinant human serum albumin (rHSA) incorporating synthetic heme with a covalently linked proximal base (albumin-heme [rHSA-hemel) is an artificial O2 carrier that can transport O2 like hemoglobin does in the blood stream. To evaluate the clinical safety of this compound, 20% and 40% exchange transfusions with rHSA-heme into anesthetized rats were followed by blood biochemical tests and histopathologic observations for 7 days. In the 20% rHSA-heme group, a total of 30 analytes by blood biochemical tests showed almost the same values as those observed in the reference 20% rHSA group. Although some abnormal values for liver parameters were found in the 40% rHSA-heme group, they returned to normal after 7 days. Histopathologic observations indicated that the administration of rHSA-heme in a volume of 20% total blood volume did not produce any negative side effects on the vital organs." @default.
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- W2000277813 date "2004-11-01" @default.
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- W2000277813 title "Safety Evaluation of an Artificial O2 Carrier as a Red Blood Cell Substitute by Blood Biochemical Tests and Histopathology Observations" @default.
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- W2000277813 doi "https://doi.org/10.1097/01.mat.0000144361.60280.da" @default.
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