FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000278109> ?p ?o ?g. }

• W2000278109 endingPage "678" @default.
• W2000278109 startingPage "673" @default.
• W2000278109 abstract "This paper discusses the effect of mass (chemical quantity) of injected dose on positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Commonly, PET or SPECT imaging study uses a “no-carrier added” dose, which contains a small amount of radioactive imaging agent (in picogram to microgram). For small animal (rodent) imaging studies, specifically targeting binding sites or biological processes, the mass (chemical quantity) in the dose may significantly modify the binding, pharmacokinetics and, ultimately, the imaging outcome. Due to differences in size and other physiological factors between humans and rodents, there is a dramatic divergence of mass effect between small animal and human imaging study. In small animal imaging studies, the mass, or effective dose (ED50), a dose required for 50% of receptor or binding site occupancy, is usually not directly related to binding potential (Bmax/Kd) (measured by in vitro binding assay). It is likely that dynamic interplays between specific and nonspecific binding in blood circulation, transient lung retention, kidney excretion, liver–gallbladder flow, soft tissue retention as well as metabolism could each play a significant role in determining the concentration of the tracer in the target regions. When using small animal imaging for studying drug occupancy (either by a pretreatment, coinjection or chasing dose), the mass effects on imaging outcome are important factors for consideration." @default.
• W2000278109 created "2016-06-24" @default.
• W2000278109 creator A5055131918 @default.
• W2000278109 creator A5087597444 @default.
• W2000278109 date "2005-10-01" @default.
• W2000278109 modified "2023-09-24" @default.
• W2000278109 title "Mass effect of injected dose in small rodent imaging by SPECT and PET" @default.
• W2000278109 cites W108301979 @default.
• W2000278109 cites W1969218941 @default.
• W2000278109 cites W1972888412 @default.
• W2000278109 cites W1974641790 @default.
• W2000278109 cites W1977566366 @default.
• W2000278109 cites W1980611143 @default.
• W2000278109 cites W1987226540 @default.
• W2000278109 cites W1989115843 @default.
• W2000278109 cites W1994750075 @default.
• W2000278109 cites W1995025219 @default.
• W2000278109 cites W1996107091 @default.
• W2000278109 cites W2007102622 @default.
• W2000278109 cites W2012746700 @default.
• W2000278109 cites W2014086933 @default.
• W2000278109 cites W2021503315 @default.
• W2000278109 cites W2022332755 @default.
• W2000278109 cites W2030633339 @default.
• W2000278109 cites W2031360672 @default.
• W2000278109 cites W2032070606 @default.
• W2000278109 cites W2033809505 @default.
• W2000278109 cites W2035347939 @default.
• W2000278109 cites W2048246008 @default.
• W2000278109 cites W2049491530 @default.
• W2000278109 cites W2056369385 @default.
• W2000278109 cites W2057605474 @default.
• W2000278109 cites W2063731167 @default.
• W2000278109 cites W2064449578 @default.
• W2000278109 cites W2068650694 @default.
• W2000278109 cites W2069036342 @default.
• W2000278109 cites W2069229423 @default.
• W2000278109 cites W2074909493 @default.
• W2000278109 cites W2080615074 @default.
• W2000278109 cites W2084826877 @default.
• W2000278109 cites W2092404798 @default.
• W2000278109 cites W2093275852 @default.
• W2000278109 cites W2093485512 @default.
• W2000278109 cites W2100718214 @default.
• W2000278109 cites W2101160808 @default.
• W2000278109 cites W2105091837 @default.
• W2000278109 cites W2106193331 @default.
• W2000278109 cites W2114644502 @default.
• W2000278109 cites W2144220495 @default.
• W2000278109 cites W2317616768 @default.
• W2000278109 doi "https://doi.org/10.1016/j.nucmedbio.2005.04.002" @default.
• W2000278109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16243641" @default.
• W2000278109 hasPublicationYear "2005" @default.
• W2000278109 type Work @default.
• W2000278109 sameAs 2000278109 @default.
• W2000278109 citedByCount "105" @default.
• W2000278109 countsByYear W20002781092012 @default.
• W2000278109 countsByYear W20002781092013 @default.
• W2000278109 countsByYear W20002781092014 @default.
• W2000278109 countsByYear W20002781092015 @default.
• W2000278109 countsByYear W20002781092016 @default.
• W2000278109 countsByYear W20002781092017 @default.
• W2000278109 countsByYear W20002781092018 @default.
• W2000278109 countsByYear W20002781092019 @default.
• W2000278109 countsByYear W20002781092020 @default.
• W2000278109 countsByYear W20002781092021 @default.
• W2000278109 countsByYear W20002781092022 @default.
• W2000278109 countsByYear W20002781092023 @default.
• W2000278109 crossrefType "journal-article" @default.
• W2000278109 hasAuthorship W2000278109A5055131918 @default.
• W2000278109 hasAuthorship W2000278109A5087597444 @default.
• W2000278109 hasConcept C112705442 @default.
• W2000278109 hasConcept C136339569 @default.
• W2000278109 hasConcept C149857219 @default.
• W2000278109 hasConcept C150903083 @default.
• W2000278109 hasConcept C177322064 @default.
• W2000278109 hasConcept C185592680 @default.
• W2000278109 hasConcept C202751555 @default.
• W2000278109 hasConcept C207001950 @default.
• W2000278109 hasConcept C2775842073 @default.
• W2000278109 hasConcept C2777807558 @default.
• W2000278109 hasConcept C29331040 @default.
• W2000278109 hasConcept C2989005 @default.
• W2000278109 hasConcept C3017724952 @default.
• W2000278109 hasConcept C55493867 @default.
• W2000278109 hasConcept C71924100 @default.
• W2000278109 hasConcept C86803240 @default.
• W2000278109 hasConcept C98274493 @default.
• W2000278109 hasConceptScore W2000278109C112705442 @default.
• W2000278109 hasConceptScore W2000278109C136339569 @default.
• W2000278109 hasConceptScore W2000278109C149857219 @default.
• W2000278109 hasConceptScore W2000278109C150903083 @default.
• W2000278109 hasConceptScore W2000278109C177322064 @default.
• W2000278109 hasConceptScore W2000278109C185592680 @default.
• W2000278109 hasConceptScore W2000278109C202751555 @default.
• W2000278109 hasConceptScore W2000278109C207001950 @default.
• W2000278109 hasConceptScore W2000278109C2775842073 @default.
• W2000278109 hasConceptScore W2000278109C2777807558 @default.

• next