FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000278115> ?p ?o ?g. }

• W2000278115 endingPage "59" @default.
• W2000278115 startingPage "48" @default.
• W2000278115 abstract "Compared to first-generation antipsychotics (FGAs) such as haloperidol, second-generation antipsychotics (SGAs) such as olanzapine are found superior to improve cognitive performance and reduce negative symptoms with no extrapyramidal symptoms (EPS). These clinical effects of SGAs have been reported to be associated with the most replicated phenomenon, favorable changes in brain regional blood flow and volume. The changes in brain regional blood flow are shown to parallel changes in angiogenesis, which is primarily mediated by vascular endothelial growth factor (VEGF) through its receptor, Flk-1, on endothelial cells. Therefore, we studied the differential effects of time-dependent treatment (14 and 45 days) with haloperidol and olanzapine (2 and 10 mg/kg/day, respectively, in drinking water) on hippocampal levels of VEGF, its receptor Flk-1, and angiogenesis in adult rat. The levels of VEGF were determined by both Western blot analysis and ELISA, and Flk-1 levels were determined by Western blot analysis. Immunohistochemical analysis of rat endothelial cell antigen-1 (RECA-1) and laminin were used to evaluate the changes in angiogenesis. After 14 days of treatment with both haloperidol and olanzapine, the levels of VEGF and angiogenesis were significantly increased (p<0.001 vs vehicle for both), but 45 days of treatment with haloperidol reduced their levels back to levels in vehicle-treated rats. However, olanzapine treatment further increased VEGF levels (p<0.05 vs levels after 14 days of treatment). Changes in the levels of Flk-1 paralleled the changes in VEGF levels. Thus, the data indicate that haloperidol and olanzapine have distinct time-dependent patterns of regulation of VEGF and angiogenesis. These changes probably provide a new molecular mechanism to better explain their differential effects on the patterns of regional blood flow and associated changes in regional volume/neuroplasticity and psychopathology." @default.
• W2000278115 created "2016-06-24" @default.
• W2000278115 creator A5024245151 @default.
• W2000278115 creator A5049536098 @default.
• W2000278115 date "2006-10-01" @default.
• W2000278115 modified "2023-10-02" @default.
• W2000278115 title "Differential effects of haloperidol and olanzapine on levels of vascular endothelial growth factor and angiogenesis in rat hippocampus" @default.
• W2000278115 cites W1561239748 @default.
• W2000278115 cites W177664770 @default.
• W2000278115 cites W1963630844 @default.
• W2000278115 cites W1966357885 @default.
• W2000278115 cites W1973461858 @default.
• W2000278115 cites W1973576041 @default.
• W2000278115 cites W1974098658 @default.
• W2000278115 cites W1979551767 @default.
• W2000278115 cites W1980969801 @default.
• W2000278115 cites W1992416895 @default.
• W2000278115 cites W2003033559 @default.
• W2000278115 cites W2004839617 @default.
• W2000278115 cites W2004907588 @default.
• W2000278115 cites W2005891675 @default.
• W2000278115 cites W2014386715 @default.
• W2000278115 cites W2020597987 @default.
• W2000278115 cites W2025149917 @default.
• W2000278115 cites W2025848769 @default.
• W2000278115 cites W2025919881 @default.
• W2000278115 cites W2027691566 @default.
• W2000278115 cites W2032196626 @default.
• W2000278115 cites W2032705729 @default.
• W2000278115 cites W2037141117 @default.
• W2000278115 cites W2042391155 @default.
• W2000278115 cites W2051021067 @default.
• W2000278115 cites W2052482464 @default.
• W2000278115 cites W2055058053 @default.
• W2000278115 cites W2060341782 @default.
• W2000278115 cites W2065453508 @default.
• W2000278115 cites W2068400560 @default.
• W2000278115 cites W2070017877 @default.
• W2000278115 cites W2074227873 @default.
• W2000278115 cites W2075728728 @default.
• W2000278115 cites W2076888875 @default.
• W2000278115 cites W2079918087 @default.
• W2000278115 cites W2088049429 @default.
• W2000278115 cites W2089909243 @default.
• W2000278115 cites W2093612777 @default.
• W2000278115 cites W2095878413 @default.
• W2000278115 cites W2096542244 @default.
• W2000278115 cites W2097659665 @default.
• W2000278115 cites W2114999955 @default.
• W2000278115 cites W2117691576 @default.
• W2000278115 cites W2120371661 @default.
• W2000278115 cites W2122752163 @default.
• W2000278115 cites W2127991992 @default.
• W2000278115 cites W2137984107 @default.
• W2000278115 cites W2147563021 @default.
• W2000278115 cites W2150311857 @default.
• W2000278115 cites W2153198085 @default.
• W2000278115 cites W2156123885 @default.
• W2000278115 cites W2159742364 @default.
• W2000278115 cites W2166398690 @default.
• W2000278115 cites W2168187353 @default.
• W2000278115 cites W2169490712 @default.
• W2000278115 cites W2262391931 @default.
• W2000278115 cites W2323525879 @default.
• W2000278115 cites W2328192696 @default.
• W2000278115 cites W2924293519 @default.
• W2000278115 doi "https://doi.org/10.1016/j.schres.2006.06.017" @default.
• W2000278115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16859894" @default.
• W2000278115 hasPublicationYear "2006" @default.
• W2000278115 type Work @default.
• W2000278115 sameAs 2000278115 @default.
• W2000278115 citedByCount "36" @default.
• W2000278115 countsByYear W20002781152012 @default.
• W2000278115 countsByYear W20002781152013 @default.
• W2000278115 countsByYear W20002781152014 @default.
• W2000278115 countsByYear W20002781152015 @default.
• W2000278115 countsByYear W20002781152016 @default.
• W2000278115 countsByYear W20002781152018 @default.
• W2000278115 countsByYear W20002781152019 @default.
• W2000278115 countsByYear W20002781152020 @default.
• W2000278115 countsByYear W20002781152021 @default.
• W2000278115 countsByYear W20002781152022 @default.
• W2000278115 countsByYear W20002781152023 @default.
• W2000278115 crossrefType "journal-article" @default.
• W2000278115 hasAuthorship W2000278115A5024245151 @default.
• W2000278115 hasAuthorship W2000278115A5049536098 @default.
• W2000278115 hasConcept C104317684 @default.
• W2000278115 hasConcept C118552586 @default.
• W2000278115 hasConcept C126322002 @default.
• W2000278115 hasConcept C134018914 @default.
• W2000278115 hasConcept C148762608 @default.
• W2000278115 hasConcept C167734588 @default.
• W2000278115 hasConcept C185592680 @default.
• W2000278115 hasConcept C2776056115 @default.
• W2000278115 hasConcept C2776412080 @default.
• W2000278115 hasConcept C2776415932 @default.
• W2000278115 hasConcept C2776619155 @default.
• W2000278115 hasConcept C2777025900 @default.

• next