Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000279084> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2000279084 endingPage "57" @default.
- W2000279084 startingPage "50" @default.
- W2000279084 abstract "Cancer cells undergo a variety of DNA copy number gains and losses (CNV), raising two important questions related to cancer development: (i) Which genes are affected? (ii) And how do CNVs, that do not represent complete deletions but do represent gene-dosage alterations, impact cancer cell functions? Recent studies have indicated that CNVs in cancer can impact genes for regulatory proteins long known to be associated with cancer development, but less is understood about CNVs affecting effector genes. Also, we have recently indicated the likely importance of transcription factor binding site (TFBS) copies in effector genes, in regulating the transition from a proliferative to an apoptotic state. Here we report data-mining analyses that indicate that copies of apoptosis-effector genes are commonly lost in cancer development, in comparison to proliferation-effector genes, and when not, apoptosis effector genes have silenced chromatin structures." @default.
- W2000279084 created "2016-06-24" @default.
- W2000279084 creator A5029216876 @default.
- W2000279084 creator A5055880373 @default.
- W2000279084 creator A5072559191 @default.
- W2000279084 creator A5087185991 @default.
- W2000279084 date "2015-01-01" @default.
- W2000279084 modified "2023-09-24" @default.
- W2000279084 title "Copy number loss or silencing of apoptosis-effector genes in cancer" @default.
- W2000279084 cites W1969916602 @default.
- W2000279084 cites W1982020575 @default.
- W2000279084 cites W1985610930 @default.
- W2000279084 cites W1988428525 @default.
- W2000279084 cites W1989773675 @default.
- W2000279084 cites W2006174787 @default.
- W2000279084 cites W2044554392 @default.
- W2000279084 cites W2094503851 @default.
- W2000279084 cites W2098282574 @default.
- W2000279084 cites W2098470595 @default.
- W2000279084 cites W2108643617 @default.
- W2000279084 cites W2146734921 @default.
- W2000279084 cites W2162223132 @default.
- W2000279084 doi "https://doi.org/10.1016/j.gene.2014.10.021" @default.
- W2000279084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25307873" @default.
- W2000279084 hasPublicationYear "2015" @default.
- W2000279084 type Work @default.
- W2000279084 sameAs 2000279084 @default.
- W2000279084 citedByCount "17" @default.
- W2000279084 countsByYear W20002790842015 @default.
- W2000279084 countsByYear W20002790842016 @default.
- W2000279084 countsByYear W20002790842017 @default.
- W2000279084 countsByYear W20002790842018 @default.
- W2000279084 countsByYear W20002790842019 @default.
- W2000279084 countsByYear W20002790842021 @default.
- W2000279084 countsByYear W20002790842022 @default.
- W2000279084 countsByYear W20002790842023 @default.
- W2000279084 crossrefType "journal-article" @default.
- W2000279084 hasAuthorship W2000279084A5029216876 @default.
- W2000279084 hasAuthorship W2000279084A5055880373 @default.
- W2000279084 hasAuthorship W2000279084A5072559191 @default.
- W2000279084 hasAuthorship W2000279084A5087185991 @default.
- W2000279084 hasConcept C104317684 @default.
- W2000279084 hasConcept C119056186 @default.
- W2000279084 hasConcept C120821319 @default.
- W2000279084 hasConcept C121608353 @default.
- W2000279084 hasConcept C141231307 @default.
- W2000279084 hasConcept C150194340 @default.
- W2000279084 hasConcept C165864922 @default.
- W2000279084 hasConcept C51785407 @default.
- W2000279084 hasConcept C54355233 @default.
- W2000279084 hasConcept C55548728 @default.
- W2000279084 hasConcept C83640560 @default.
- W2000279084 hasConcept C86339819 @default.
- W2000279084 hasConcept C86803240 @default.
- W2000279084 hasConcept C95444343 @default.
- W2000279084 hasConcept C96232424 @default.
- W2000279084 hasConceptScore W2000279084C104317684 @default.
- W2000279084 hasConceptScore W2000279084C119056186 @default.
- W2000279084 hasConceptScore W2000279084C120821319 @default.
- W2000279084 hasConceptScore W2000279084C121608353 @default.
- W2000279084 hasConceptScore W2000279084C141231307 @default.
- W2000279084 hasConceptScore W2000279084C150194340 @default.
- W2000279084 hasConceptScore W2000279084C165864922 @default.
- W2000279084 hasConceptScore W2000279084C51785407 @default.
- W2000279084 hasConceptScore W2000279084C54355233 @default.
- W2000279084 hasConceptScore W2000279084C55548728 @default.
- W2000279084 hasConceptScore W2000279084C83640560 @default.
- W2000279084 hasConceptScore W2000279084C86339819 @default.
- W2000279084 hasConceptScore W2000279084C86803240 @default.
- W2000279084 hasConceptScore W2000279084C95444343 @default.
- W2000279084 hasConceptScore W2000279084C96232424 @default.
- W2000279084 hasIssue "1" @default.
- W2000279084 hasLocation W20002790841 @default.
- W2000279084 hasLocation W20002790842 @default.
- W2000279084 hasOpenAccess W2000279084 @default.
- W2000279084 hasPrimaryLocation W20002790841 @default.
- W2000279084 hasRelatedWork W2048299411 @default.
- W2000279084 hasRelatedWork W2059282377 @default.
- W2000279084 hasRelatedWork W2083540239 @default.
- W2000279084 hasRelatedWork W2125934144 @default.
- W2000279084 hasRelatedWork W2393232383 @default.
- W2000279084 hasRelatedWork W2765081400 @default.
- W2000279084 hasRelatedWork W2984359285 @default.
- W2000279084 hasRelatedWork W3083870051 @default.
- W2000279084 hasRelatedWork W3091507900 @default.
- W2000279084 hasRelatedWork W997738386 @default.
- W2000279084 hasVolume "554" @default.
- W2000279084 isParatext "false" @default.
- W2000279084 isRetracted "false" @default.
- W2000279084 magId "2000279084" @default.
- W2000279084 workType "article" @default.