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• W2000281409 abstract "Background: In neonates treated with recombinant human protein(rHuEPO) for anemia of prematurity low neutrophil (PMN) counts have been observed by certain investigators. In addition, the production of PMN by fetal haemopoietic progenitors appears to be down-modulated in vitro.Objective: To assess the possible influence of administration of r-HuEPO in association with iron on PMN antimicrobial function.Method: As part of a randomized controlled study, 17 premature neonates with BW<1300 gr, GA≤31 wk were randomized to receive either 200 U/kg/every other day rHuEPO + 12 mg/kg/d iron (EPO+high Fe, n=7) or 200 U/kg/every other day rHuEPO + 4 mg/kg/d iron (EPO + standard Fe, n=5) or 4 mg/kg/d iron only (standard Fe, n=5). All infants were given oral folate and vit E supplementation. PMN counts were measured during the treatment period and two weeks after discharge. PMN were isolated from venus blood of these neonates (mean ± SE 60±5 days after birth) and from 8 healthy young adults by dextran sedimentation/ficoll centrifugation. Random migration and chemotaxis to bacterial product analogue N-formyl methionyl leucyl phenylalanine (FMLP), phagocytic activity evaluated as% phagocytosis of Staphylococcus aureus bacteria (% of phagocytosing PMN) as well as weighted phagocytic index (WPI, index of average number of intracellular bacteria per PMN), and oxidative burst measured as O2-production in response to FMLP were evaluated. Results: The 3 groups of neonates had PMN counts 8.4±3.5, 9.8±3.1 and 7.6±1.8 (x 103/μl) respectively the day of discharge. No differences between neonates and adult controls were found in random migration and chemotactic activity as well as in O2-production. (O2- of neonates was 4.3±0.8 nmoles/0.5*106 PMN/15 min as compared to 2.4±0.7 of adults, p=0.11). Both% phagocytosis and WPI of neonates (90.2±2.2% and 3.0±0.1, respectively) were similar to those of adults(91.9±4.4% and 3.2±0.2). In addition, no significant differences were detected among EPO + high Fe EPO + standard Fe and standard Fe groups of neonates and adult controls in chemotaxis, O2-and WPI. In contrast, there were significant differences between EPO + high Fe and EPO + standard Fe as well as between EPO + standard Fe and standard Fe groups in% phagocytosis(93.6±3.3% vs. 81.8±4.0% vs. 93.8±1.8%, respectively, ANOVA with Bonferroni p<0.01). However, there was no increased incidence of infection in EPO + standard Fe group compared to the other neonates.Conclusion: A modest impairment of phagocytic activity of neonatal PMN was found to occur in association with administration of rHuEPO and standard iron as compared to iron alone and to administration of rHuEPO combined with high iron dose. This may be related to consumption of iron during rHuEPO-enhanced erythropoiesis." @default.
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• W2000281409 date "1997-05-01" @default.
• W2000281409 modified "2023-10-18" @default.
• W2000281409 title "INFLUENCE OF r-HuEPO ON NEUTROPHIL FUNCTION IN PREMATURE NEONATES. 76" @default.
• W2000281409 doi "https://doi.org/10.1203/00006450-199705000-00095" @default.
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